{"id":"W4410945962","doi":"10.1016/j.oret.2025.05.030","title":"TALON Phase IIIb Study: 32-Week Primary Results of Brolucizumab Using Treat and Extend for Neovascular Age-Related Macular Degeneration","year":2025,"lang":"en","type":"article","venue":"Ophthalmology Retina","topic":"Retinal Diseases and Treatments","field":"Medicine","cited_by":5,"is_retracted":false,"has_abstract":false,"ca_institutions":"Health Sciences Centre; Sunnybrook Health Science Centre","funders":"Novartis Animal Health; Novartis","keywords":"Medicine; Macular degeneration; Ophthalmology; Optometry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001367898,0.001460954,0.001925666,0.0003471386,0.0004316398,0.001536958,0.0008237193,0.00151448,0.006418075],"category_scores_gemma":[0.000795772,0.0004018808,0.002167736,0.000249329,0.000821193,0.0009487948,0.000307177,0.003721159,0.001703356],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0009733254,"about_ca_system_score_gemma":0.001091804,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001515767,"about_ca_topic_score_gemma":0.004351824,"domain_scores_codex":[0.9996916,0.00009804333,0.00001285446,0.00004747576,0.000034398,0.0001156298],"domain_scores_gemma":[0.9995567,0.00006718139,0.00008542438,0.00004611105,0.00003355712,0.0002109658],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.7745372,0.03065431,0.003157206,0.001933283,0.002320752,0.0002716404,0.0003134528,0.002682083,0.02487875,0.00121615,0.01954245,0.1384927],"study_design_scores_gemma":[0.8240008,0.1573653,0.007514971,0.0001251998,0.0006940141,0.0002268712,0.00009276379,0.001135911,0.001942893,0.0005071701,0.006347552,0.00004657864],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9717525,0.008853653,0.001467755,0.001816117,0.0007525738,0.002845882,0.003305455,0.0003570039,0.008848909],"genre_scores_gemma":[0.9639976,0.004606145,0.002346886,0.003546179,0.0004794282,0.002813742,0.004034958,0.0001126604,0.01806238],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006418075,"threshold_uncertainty_score":0.02147061,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0367554474073126,"score_gpt":0.3640554965416821,"score_spread":0.3273000491343695,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}