{"id":"W4410948784","doi":"10.21203/rs.3.rs-6270917/v1","title":"Genomic characterization of Candida parapsilosis hospital isolates revealed the spread and persistence of a fluconazole-resistant cluster associated with increased erg11 copies","year":2025,"lang":"en","type":"preprint","venue":"Research Square","topic":"Antifungal resistance and susceptibility","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"McMaster University","funders":"Medical Research Council; Alliance de recherche numérique du Canada; University of British Columbia; Simon Fraser University; Nanyang Technological University; Sidra Medicine; McMaster University; Hamad Medical Corporation","keywords":"Persistence (discontinuity); Candida parapsilosis; Fluconazole; Biology; Cluster (spacecraft); Microbiology; Antifungal; Computer science","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001278018,0.0004561841,0.0002447909,0.000895794,0.0002981829,0.0006006657,0.000157231,0.0004686744,0.001889326],"category_scores_gemma":[0.0007218926,0.0001165954,0.0003850092,0.000761901,0.0002434744,0.000106935,0.0002834863,0.0003811662,0.0006098197],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000194585,"about_ca_system_score_gemma":0.0002219414,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002860763,"about_ca_topic_score_gemma":0.002133067,"domain_scores_codex":[0.9997709,0.00002045987,0.00002355245,0.00007223225,0.00005086257,0.00006193756],"domain_scores_gemma":[0.9997076,0.0001021811,0.00005457317,0.00003823172,0.00005344785,0.00004389102],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0007115595,0.00009887767,0.04455878,0.0001098665,0.00006181544,0.003873531,0.0006629264,0.0003639597,0.9367232,0.0002923997,0.0005413239,0.01200179],"study_design_scores_gemma":[0.00003450543,0.0005798343,0.6898893,0.00004971744,0.0001765493,0.01106182,0.001711794,0.002213899,0.287403,0.0004360735,0.006404815,0.00003868374],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.990813,0.0001887971,0.001644132,0.0001921228,0.00002495336,0.00003866625,0.005391615,0.00006050435,0.001646233],"genre_scores_gemma":[0.9936553,0.0001441115,0.001199867,0.0000676573,0.0000136721,0.00001276708,0.003771319,0.00002194702,0.001113386],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002860763,"threshold_uncertainty_score":0.006320417,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0295446088332991,"score_gpt":0.3131934717273744,"score_spread":0.2836488628940753,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}