{"id":"W4410949005","doi":"10.1007/s13555-025-01443-w","title":"Rapid Itch Improvement and Skin Clearance with Upadacitinib Versus Placebo (Measure Up 1 and Measure Up 2) and Versus Dupilumab (Heads Up): Results from Three Phase 3 Clinical Trials in Patients with Moderate-to-Severe Atopic Dermatitis","year":2025,"lang":"en","type":"article","venue":"Dermatology and Therapy","topic":"Dermatology and Skin Diseases","field":"Medicine","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"Probity Medical Research; SKiN Health; University of Calgary","funders":"AbbVie","keywords":"Eczema Area and Severity Index; Medicine; Placebo; Dupilumab; Atopic dermatitis; Dermatology Life Quality Index; Clinical trial; Quality of life (healthcare); Internal medicine; Dermatology; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002371347,0.0008269323,0.001638128,0.000391719,0.0002992632,0.0007371798,0.0004667119,0.0006833489,0.001665516],"category_scores_gemma":[0.00153716,0.0003251558,0.002127041,0.0004118483,0.0006323523,0.0007697457,0.0003096632,0.00200463,0.0001839241],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005499985,"about_ca_system_score_gemma":0.0007187212,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004669286,"about_ca_topic_score_gemma":0.001912923,"domain_scores_codex":[0.9992552,0.0004038389,0.00006663155,0.00009261379,0.00008852613,0.00009322292],"domain_scores_gemma":[0.9988901,0.000317874,0.0003987604,0.0000666311,0.0000601548,0.0002664524],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.790378,0.02173296,0.006111063,0.002862294,0.004254784,0.0001462631,0.0002114707,0.002563435,0.02022925,0.0002940564,0.002459965,0.1487565],"study_design_scores_gemma":[0.4353817,0.5204301,0.02830905,0.0001829949,0.003242051,0.0003974867,0.0001026458,0.002061183,0.007671781,0.0003834069,0.001762797,0.0000747907],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9886417,0.008054745,0.0003729489,0.0002341109,0.0001132813,0.0007502207,0.0004827296,0.00006007759,0.00129026],"genre_scores_gemma":[0.9962109,0.001724485,0.0005226461,0.000263076,0.00007580882,0.000472848,0.000351136,0.000005593671,0.000373477],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002371347,"threshold_uncertainty_score":0.012541,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05213852253535708,"score_gpt":0.3451427297532532,"score_spread":0.2930042072178961,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}