{"id":"W4410949387","doi":"10.1093/brain/awaf194","title":"Mild behavioural impairment-apathy and core Alzheimer's disease cerebrospinal fluid biomarkers","year":2025,"lang":"en","type":"article","venue":"Brain","topic":"Health, Environment, Cognitive Aging","field":"Environmental Science","cited_by":10,"is_retracted":false,"has_abstract":true,"ca_institutions":"Alberta Children's Hospital; University of Calgary","funders":"National Institute of Biomedical Imaging and Bioengineering; Canadian Institutes of Health Research; National Institutes of Health; Genentech; IXICO; DoD Alzheimer's Disease Neuroimaging Initiative; H. Lundbeck A/S; Servier; Eisai; National Institute for Health and Care Research; Northern California Institute for Research and Education; Pfizer; Novartis Pharmaceuticals Corporation; University of Southern California; Biogen; Eli Lilly and Company; Bristol-Myers Squibb; BioClinica; U.S. Department of Defense; Alzheimer's Disease Neuroimaging Initiative; Meso Scale Diagnostics; National Institute on Aging; Alzheimer's Association","keywords":"Apathy; Cerebrospinal fluid; Medicine; Disease; Alzheimer's disease; Neuroscience; Psychology; Pathology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0009853852,0.0007971666,0.0006005868,0.001010852,0.0003308172,0.00102815,0.0005231313,0.0004133437,0.002053052],"category_scores_gemma":[0.003820609,0.0002405399,0.00102605,0.001113392,0.0003203361,0.0004643792,0.0007591007,0.0008023561,0.0002953393],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005383015,"about_ca_system_score_gemma":0.0006668739,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.01367032,"about_ca_topic_score_gemma":0.01175229,"domain_scores_codex":[0.9994817,0.000156246,0.00006525171,0.0001230786,0.0001017014,0.00007191159],"domain_scores_gemma":[0.9981579,0.0003410284,0.0008515046,0.0001800078,0.0002003048,0.0002692911],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.000530394,0.00009408302,0.9937225,0.00005193385,0.0004416082,0.0001114678,0.00007825618,0.0003941193,0.0002212462,0.00005988733,0.0001814871,0.004112914],"study_design_scores_gemma":[0.0000130511,0.0001828826,0.9983016,0.00001380946,0.00008892143,0.0002290094,0.00004809952,0.0006118079,0.00006769362,0.0001895242,0.0002478435,0.000005626308],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9963441,0.0006565037,0.0002993586,0.00006109365,0.000009890293,0.00003367213,0.001344744,0.00002261395,0.001227978],"genre_scores_gemma":[0.998727,0.000119148,0.0001429301,0.00001548527,0.000007782985,0.00002237311,0.000482361,0.000001983069,0.0004810027],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01367032,"threshold_uncertainty_score":0.02718151,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02470603116065105,"score_gpt":0.2804449842418911,"score_spread":0.25573895308124,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}