{"id":"W4410955176","doi":"10.1001/jamaneurol.2025.1481","title":"Prognostic Factors for Multiple Sclerosis Symptoms in Radiologically Isolated Syndrome","year":2025,"lang":"en","type":"article","venue":"JAMA Neurology","topic":"Multiple Sclerosis Research Studies","field":"Medicine","cited_by":19,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Cilag; NIH Clinical Center; Sanofi Genzyme; EMD Serono; Celgene; Amsterdam Neuroscience; Chugai Pharmaceutical; MedDay Pharmaceuticals; Ipsen; Mylan; Universitat Autònoma de Barcelona; National Research Foundation; Universidad de Alcalá; Institut National de la Santé et de la Recherche Médicale; Karl-Franzens-Universität Graz; Deutsche Forschungsgemeinschaft; Multiple Sclerosis Society; Vrije Universiteit Amsterdam; International Progressive MS Alliance; Horizon Therapeutics; Medizinische Universität Graz; Universitätsmedizin Göttingen; Universitat de Barcelona; Centre National de la Recherche Scientifique; Medizinische Universität Innsbruck; European Commission; Inselspital, Universitätsspital Bern; Sanofi; TG Therapeutics; Amsterdam University Medical Centers; Universität Innsbruck; Bundesministerium für Bildung und Forschung; Merck KGaA; F. Hoffmann-La Roche; American University of Beirut; University of Victoria; Hexal AG; Biogen; Alexion Pharmaceuticals; Neuraxpharm; Bristol-Myers Squibb; Teva Pharmaceutical Industries; Massachusetts General Hospital; University of Bern; CSL Behring; Eli Lilly and Company; Samsung; Instituto de Salud Carlos III; Amgen","keywords":"Medicine; Hazard ratio; Internal medicine; Proportional hazards model; Multiple sclerosis; Magnetic resonance imaging; Clinically isolated syndrome; Cohort; McDonald criteria; Gastroenterology; Confidence interval; Immunology; Radiology","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000897767,0.0005314704,0.0003376971,0.0007573121,0.0002879087,0.000512202,0.0004384164,0.0005208885,0.002461134],"category_scores_gemma":[0.004611373,0.0002521216,0.0005875914,0.0008922261,0.0004338467,0.000495002,0.0005466023,0.0007366359,0.0002425286],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001668991,"about_ca_system_score_gemma":0.00040814,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001450839,"about_ca_topic_score_gemma":0.001987536,"domain_scores_codex":[0.9994978,0.0001497704,0.00005394899,0.0001117786,0.0001037414,0.00008295084],"domain_scores_gemma":[0.9962301,0.0006975533,0.002297481,0.0001522136,0.0002086021,0.0004139612],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.00009104926,0.00001069107,0.9988474,0.000005601916,0.00002836822,0.00007693366,0.00001484286,0.00002745811,0.00009977827,0.000006439329,0.00003956322,0.000751834],"study_design_scores_gemma":[0.000006061565,0.00007697183,0.9989779,0.000009653588,0.00002509405,0.0005357338,0.00004606027,0.0001863983,0.00004904539,0.00003240877,0.00005156769,0.000003174457],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9988818,0.000425903,0.0001707695,0.000089243,0.000009176779,0.000004993708,0.0001839798,0.000006823663,0.0002274037],"genre_scores_gemma":[0.9994903,0.00009579944,0.0001092407,0.00001181212,0.00001869051,0.000003368277,0.0002038114,0.000001990276,0.0000650916],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002461134,"threshold_uncertainty_score":0.008233309,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05353661764197934,"score_gpt":0.2991225708640355,"score_spread":0.2455859532220561,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}