{"id":"W4410955176","doi":"10.1001/jamaneurol.2025.1481","title":"Prognostic Factors for Multiple Sclerosis Symptoms in Radiologically Isolated Syndrome","year":2025,"lang":"en","type":"article","venue":"JAMA Neurology","topic":"Multiple Sclerosis Research Studies","field":"Medicine","cited_by":19,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Cilag; NIH Clinical Center; Sanofi Genzyme; EMD Serono; Celgene; Amsterdam Neuroscience; Chugai Pharmaceutical; MedDay Pharmaceuticals; Ipsen; Mylan; Universitat Autònoma de Barcelona; National Research Foundation; Universidad de Alcalá; Institut National de la Santé et de la Recherche Médicale; Karl-Franzens-Universität Graz; Deutsche Forschungsgemeinschaft; Multiple Sclerosis Society; Vrije Universiteit Amsterdam; International Progressive MS Alliance; Horizon Therapeutics; Medizinische Universität Graz; Universitätsmedizin Göttingen; Universitat de Barcelona; Centre National de la Recherche Scientifique; Medizinische Universität Innsbruck; European Commission; Inselspital, Universitätsspital Bern; Sanofi; TG Therapeutics; Amsterdam University Medical Centers; Universität Innsbruck; Bundesministerium für Bildung und Forschung; Merck KGaA; F. Hoffmann-La Roche; American University of Beirut; University of Victoria; Hexal AG; Biogen; Alexion Pharmaceuticals; Neuraxpharm; Bristol-Myers Squibb; Teva Pharmaceutical Industries; Massachusetts General Hospital; University of Bern; CSL Behring; Eli Lilly and Company; Samsung; Instituto de Salud Carlos III; Amgen","keywords":"Medicine; Hazard ratio; Internal medicine; Proportional hazards model; Multiple sclerosis; Magnetic resonance imaging; Clinically isolated syndrome; Cohort; McDonald criteria; Gastroenterology; Confidence interval; Immunology; Radiology","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002915905,0.000243565,0.0006839237,0.000433441,0.000111887,0.00002425749,0.0002254201,0.0004036732,0.00004451552],"category_scores_gemma":[0.008283561,0.0001888048,0.0001545897,0.0005355882,0.0002433019,0.00006657803,0.0001894205,0.0006788851,0.00001533869],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005859109,"about_ca_system_score_gemma":0.00009081537,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00006459513,"about_ca_topic_score_gemma":0.00006766358,"domain_scores_codex":[0.9978606,0.0002082558,0.0004476659,0.0006035027,0.00016804,0.0007119282],"domain_scores_gemma":[0.996075,0.003241568,0.00007015153,0.0003361478,0.0001522123,0.000124863],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.002110572,0.0003420571,0.9774709,0.0001496744,0.0001561063,0.00009538193,0.0001096432,0.00003099632,0.01269993,0.00008471265,0.001761211,0.004988777],"study_design_scores_gemma":[0.005311107,0.00269696,0.983809,0.00009158115,0.00004407881,0.00002995084,0.00002317649,0.005392964,0.0001843034,0.00007773193,0.002214343,0.0001248155],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9884269,0.0003237452,0.0003266257,0.00808993,0.0002555298,0.002083784,0.00003226197,0.0001454171,0.0003158719],"genre_scores_gemma":[0.996401,0.0003281908,0.0001662027,0.002282797,0.00004519318,0.0005189728,0.0000436348,0.00002350917,0.0001905545],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01251563,"threshold_uncertainty_score":0.9916794,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05353661764197934,"score_gpt":0.2991225708640355,"score_spread":0.2455859532220561,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}