{"id":"W4410962802","doi":"10.1038/s41573-025-01211-7","title":"The gut microbiome as a target in cancer immunotherapy: opportunities and challenges for drug development","year":2025,"lang":"en","type":"review","venue":"Nature Reviews Drug Discovery","topic":"Gut microbiota and health","field":"Biochemistry, Genetics and Molecular Biology","cited_by":50,"is_retracted":false,"has_abstract":false,"ca_institutions":"London Health Sciences Centre; Western University; McGill University Health Centre; McGill University; Centre Hospitalier de l’Université de Montréal","funders":"","keywords":"Microbiome; Gut microbiome; Drug development; Cancer; Computational biology; Drug; Cancer immunotherapy; Immunotherapy; Drug discovery; Medicine; Biology; Bioinformatics; Pharmacology; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.001115383,0.0005973433,0.001528287,0.0001349849,0.0001893719,0.0001050072,0.0005065122,0.0006006282,0.000003651751],"category_scores_gemma":[0.00008151427,0.0003714923,0.0004536785,0.0001316771,0.00009821978,0.00001078939,0.0002156784,0.0005548077,0.000002391336],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001240733,"about_ca_system_score_gemma":0.00204122,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002027392,"about_ca_topic_score_gemma":0.0005569712,"domain_scores_codex":[0.9975372,0.0003459653,0.0008698279,0.0006906927,0.00008781611,0.0004685294],"domain_scores_gemma":[0.9987513,0.0001322786,0.0004529909,0.0005412599,0.00005981755,0.00006230446],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00002345234,0.00004141101,9.19719e-7,0.04554703,0.0001670819,0.000001575889,0.0001162551,3.075471e-8,0.0001048664,0.0002752284,0.0156458,0.9380764],"study_design_scores_gemma":[0.0002301916,0.00001796977,0.000005903793,0.01701309,0.0000970773,0.00001141218,0.00007393522,2.54302e-8,0.00004334275,0.00002611207,0.9820793,0.0004016761],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.00002810022,0.9949871,0.000003788903,0.001290507,0.0005535228,0.002742957,0.0002038642,0.000009835544,0.0001803647],"genre_scores_gemma":[0.000002621611,0.9863278,0.0002437963,0.0007750166,0.0002280011,0.001389997,0.0006246276,0.00007244677,0.01033572],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9664335,"threshold_uncertainty_score":0.9998737,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04844827316399215,"score_gpt":0.361772592208485,"score_spread":0.3133243190444928,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}