{"id":"W4410963787","doi":"10.21203/rs.3.rs-5928514/v1","title":"Rare missense variants of the leukocyte common antigen related receptor (LAR) display reduced activity in transcellular adhesion and synapse formation","year":2025,"lang":"en","type":"preprint","venue":"Research Square","topic":"Cell Adhesion Molecules Research","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"Montreal Clinical Research Institute","funders":"Fonds de Recherche du Québec - Santé; Canadian Institutes of Health Research; National Institutes of Health; Lundbeckfonden; H. Lundbeck A/S; Novo Nordisk Fonden; National Institute of Mental Health; Novo Nordisk; Aarhus Universitet","keywords":"Transcellular; Missense mutation; Synapse; Immunological synapse; Receptor; Cell biology; Antigen; Chemistry; Biology; Immunology; Neuroscience; Genetics; Mutation; T-cell receptor; Gene; T cell; Immune system","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002113186,0.0008180416,0.0005225071,0.0005542828,0.000265717,0.0005045749,0.0003593053,0.001153805,0.004530405],"category_scores_gemma":[0.0009292061,0.0001858518,0.0004849383,0.0004724176,0.0004991362,0.0001509389,0.0003650138,0.0007340368,0.0008745786],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001610816,"about_ca_system_score_gemma":0.0001071969,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007548695,"about_ca_topic_score_gemma":0.0006932132,"domain_scores_codex":[0.9995803,0.00009312829,0.00006154102,0.0001060949,0.00009908125,0.00005987637],"domain_scores_gemma":[0.9993305,0.0002807356,0.0001841396,0.00006972672,0.00004010374,0.00009474743],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002607861,0.0001546421,0.0173556,0.0001364464,0.0004401993,0.01982523,0.0002730738,0.0006279993,0.94681,0.001241489,0.001173746,0.009353683],"study_design_scores_gemma":[0.0009142632,0.002002066,0.437425,0.0001148566,0.001687809,0.15638,0.0008184605,0.006417227,0.3761628,0.003187576,0.01472813,0.0001616764],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9959961,0.0005313817,0.001588588,0.0001116614,0.00007222092,0.000009875717,0.0007686462,0.00007863782,0.0008429639],"genre_scores_gemma":[0.9978718,0.0001418873,0.000567948,0.00006099331,0.00004015595,0.00000938277,0.0004131458,0.00004410597,0.0008505528],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004530405,"threshold_uncertainty_score":0.01515567,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04523409406791286,"score_gpt":0.369847671852261,"score_spread":0.3246135777843481,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}