{"id":"W4410973966","doi":"10.1038/s41591-025-03739-y","title":"Anti-sporozoite monoclonal antibody for malaria prevention: secondary efficacy outcome of a phase 2 randomized trial","year":2025,"lang":"en","type":"article","venue":"Nature Medicine","topic":"Malaria Research and Control","field":"Medicine","cited_by":10,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Infection and Immunity","funders":"National Institute of Allergy and Infectious Diseases; NHLBI Division of Intramural Research; National Institutes of Health; Division of Intramural Research, National Institute of Allergy and Infectious Diseases; Bill and Melinda Gates Foundation","keywords":"Monoclonal antibody; Randomized controlled trial; Malaria; Medicine; Monoclonal; Virology; Antibody; Immunology; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.005100926,0.002215898,0.002909777,0.0005894692,0.0004612911,0.00145401,0.0007686093,0.002565455,0.007259227],"category_scores_gemma":[0.003726461,0.0007174139,0.002438361,0.0004228804,0.0009984928,0.001332092,0.0005514472,0.00270945,0.001006346],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000651113,"about_ca_system_score_gemma":0.0009828855,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004028568,"about_ca_topic_score_gemma":0.0006629328,"domain_scores_codex":[0.9976775,0.001508699,0.0001142282,0.0002992208,0.0001623918,0.0002380801],"domain_scores_gemma":[0.9982051,0.0005597927,0.0004862476,0.0001414566,0.0002145725,0.000392932],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9820569,0.004140192,0.0007831386,0.000768177,0.001383641,0.0000391097,0.00003215803,0.000252115,0.002483914,0.0001325687,0.0008672159,0.007060923],"study_design_scores_gemma":[0.9133359,0.08100262,0.00246958,0.00005616293,0.0008977688,0.00003137867,0.00001649332,0.0005319751,0.000541459,0.0002073625,0.0008925984,0.00001667548],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.961091,0.008605875,0.00284532,0.001539041,0.001516425,0.01648477,0.003155983,0.0002185075,0.004542968],"genre_scores_gemma":[0.9620142,0.002815305,0.003336607,0.002448265,0.001376081,0.02078436,0.002388188,0.00004863543,0.004788408],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.007259227,"threshold_uncertainty_score":0.02697659,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01913028161273075,"score_gpt":0.4223010765280774,"score_spread":0.4031707949153466,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}