{"id":"W4410974562","doi":"10.1002/rcm.10071","title":"Advantages of Incomplete Digestion in Human Hair Shaft Proteomics, a Focus on Cuticular Keratins","year":2025,"lang":"en","type":"article","venue":"Rapid Communications in Mass Spectrometry","topic":"Skin and Cellular Biology Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Simon Fraser University","funders":"British Columbia Knowledge Development Fund; Natural Sciences and Engineering Research Council of Canada; Canada Foundation for Innovation","keywords":"Keratin; Proteolysis; Hair shaft; Chemistry; Digestion (alchemy); Chromatography; Proteome; Sample preparation; Proteomics; Shampoo; Mass spectrometry; Homogenizer; Biochemistry; Hair follicle; Biology; Enzyme; Cell biology; Organic chemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001644712,0.0004901044,0.0004415874,0.000442744,0.0003536518,0.000738399,0.0003242466,0.0004811229,0.001068956],"category_scores_gemma":[0.001405387,0.0002586325,0.0003963549,0.0003270769,0.0004414229,0.0004731613,0.0006157403,0.0006164311,0.0004888076],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002127056,"about_ca_system_score_gemma":0.0004288522,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005404495,"about_ca_topic_score_gemma":0.001187612,"domain_scores_codex":[0.9988686,0.0003240494,0.00008967899,0.0003304807,0.0003101758,0.00007711203],"domain_scores_gemma":[0.9991116,0.0002784185,0.0001658973,0.0001356533,0.0002283635,0.00008003943],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001174233,0.00001214797,0.001419399,0.0001559985,0.00002832342,0.00009173201,0.00003261591,0.0001060168,0.992967,0.000071327,0.0001234959,0.004874497],"study_design_scores_gemma":[0.00001681257,0.0002317233,0.02831678,0.00005508053,0.0001132166,0.001847661,0.0001003855,0.00233631,0.958601,0.0004273321,0.007930791,0.00002283777],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8710779,0.01772501,0.1062461,0.0009767141,0.0002292901,0.0001448114,0.001170455,0.0004145542,0.002015165],"genre_scores_gemma":[0.8906095,0.005488466,0.09985535,0.0006856582,0.0001132477,0.0000959848,0.00125729,0.0001657002,0.001728736],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001644712,"threshold_uncertainty_score":0.008698165,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01711550525805288,"score_gpt":0.3301387907476508,"score_spread":0.313023285489598,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}