{"id":"W4410974562","doi":"10.1002/rcm.10071","title":"Advantages of Incomplete Digestion in Human Hair Shaft Proteomics, a Focus on Cuticular Keratins","year":2025,"lang":"en","type":"article","venue":"Rapid Communications in Mass Spectrometry","topic":"Skin and Cellular Biology Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Simon Fraser University","funders":"British Columbia Knowledge Development Fund; Natural Sciences and Engineering Research Council of Canada; Canada Foundation for Innovation","keywords":"Keratin; Proteolysis; Hair shaft; Chemistry; Digestion (alchemy); Chromatography; Proteome; Sample preparation; Proteomics; Shampoo; Mass spectrometry; Homogenizer; Biochemistry; Hair follicle; Biology; Enzyme; Cell biology; Organic chemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000516945,0.0001371724,0.0002198101,0.0005188352,0.000101553,0.00001425492,0.0008445893,0.0001788086,0.00001834405],"category_scores_gemma":[0.0001922805,0.000143159,0.00007657136,0.0006192185,0.0002503854,0.000004295503,0.0003571821,0.0003750995,0.00000349707],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00007781723,"about_ca_system_score_gemma":0.00007836901,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00006522515,"about_ca_topic_score_gemma":0.0002020118,"domain_scores_codex":[0.9986165,0.0003858038,0.0003685677,0.0002886826,0.000100778,0.0002396397],"domain_scores_gemma":[0.9982728,0.00007140478,0.00008467715,0.001490245,0.00005303846,0.00002778047],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005777955,0.0003425714,0.06571245,0.00002115187,0.00003837687,0.00000262052,0.00002173373,0.00003566949,0.9144242,0.01858832,0.00004594958,0.000709183],"study_design_scores_gemma":[0.00168057,0.0006667815,0.0996989,0.0001868177,0.00001312734,0.000008227262,0.0002283828,0.0006349283,0.885666,0.009449293,0.001480581,0.0002864405],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9810479,0.003046458,0.002186758,0.001642834,0.00003472604,0.0005724949,0.00001743587,0.00001358326,0.01143781],"genre_scores_gemma":[0.9899784,0.001448792,0.007982714,0.00004877418,0.00001776058,0.0001211735,0.0001920093,0.00001221053,0.0001981654],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03398645,"threshold_uncertainty_score":0.5837855,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01711550525805288,"score_gpt":0.3301387907476508,"score_spread":0.313023285489598,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}