{"id":"W4410975252","doi":"10.1111/ejh.14426","title":"Sensitization of Non‐<scp>M3</scp> Acute Myeloid Leukemia Blasts to All‐<i>Trans</i> Retinoic Acid by the <scp>LSD1</scp> Inhibitor Tranylcypromine: <scp>TRANSATRA</scp> Phase I Study","year":2025,"lang":"en","type":"article","venue":"European Journal Of Haematology","topic":"Retinoids in leukemia and cellular processes","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hamilton Health Sciences; McMaster University; Population Health Research Institute","funders":"Deutschen Konsortium für Translationale Krebsforschung","keywords":"Retinoic acid; Tranylcypromine; Myeloid leukemia; Sensitization; Myeloid; Chemistry; Tretinoin; Cancer research; Pharmacology; Medicine; Immunology; Biochemistry; Gene; Enzyme","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0009982716,0.0007567555,0.00119803,0.0002792748,0.000321527,0.0004432636,0.0006320435,0.000609802,0.002503911],"category_scores_gemma":[0.0004194869,0.0003647514,0.0007494903,0.0002676058,0.0005722806,0.0003259068,0.000226155,0.001838985,0.0005430326],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004324769,"about_ca_system_score_gemma":0.0008209966,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006168014,"about_ca_topic_score_gemma":0.001212045,"domain_scores_codex":[0.9996605,0.000178512,0.00002506949,0.00004293511,0.00003622512,0.00005676928],"domain_scores_gemma":[0.9995803,0.00009041778,0.00006895053,0.00006323686,0.00002750899,0.0001694541],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.2350977,0.07140941,0.005315186,0.0008049196,0.0006839561,0.0005152256,0.0004552211,0.004283014,0.6086707,0.0005021752,0.003405221,0.06885733],"study_design_scores_gemma":[0.1088262,0.7582346,0.01488496,0.00003765425,0.0003404646,0.0007065955,0.00008984296,0.002647748,0.1105701,0.0001972298,0.00343279,0.0000319016],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9979147,0.0004057105,0.0003445906,0.00006322295,0.00002282155,0.0004821823,0.0002051301,0.00003443317,0.00052706],"genre_scores_gemma":[0.9969433,0.0004535723,0.0005969258,0.0001013686,0.00004016304,0.000500444,0.0005053409,0.00001384303,0.0008449718],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002503911,"threshold_uncertainty_score":0.00837636,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006219842120234684,"score_gpt":0.2522489308301076,"score_spread":0.2460290887098729,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}