{"id":"W4410975252","doi":"10.1111/ejh.14426","title":"Sensitization of Non‐<scp>M3</scp> Acute Myeloid Leukemia Blasts to All‐<i>Trans</i> Retinoic Acid by the <scp>LSD1</scp> Inhibitor Tranylcypromine: <scp>TRANSATRA</scp> Phase I Study","year":2025,"lang":"en","type":"article","venue":"European Journal Of Haematology","topic":"Retinoids in leukemia and cellular processes","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hamilton Health Sciences; McMaster University; Population Health Research Institute","funders":"Deutschen Konsortium für Translationale Krebsforschung","keywords":"Retinoic acid; Tranylcypromine; Myeloid leukemia; Sensitization; Myeloid; Chemistry; Tretinoin; Cancer research; Pharmacology; Medicine; Immunology; Biochemistry; Gene; Enzyme","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.001705851,0.0006493661,0.00106661,0.0002977503,0.000242722,0.00009610182,0.001237675,0.0002916514,0.000005863034],"category_scores_gemma":[0.001041468,0.000526064,0.0004579742,0.0006052561,0.0004543418,0.00003869085,0.0001828096,0.0007889367,0.0000221716],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006707365,"about_ca_system_score_gemma":0.0005054727,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000003432884,"about_ca_topic_score_gemma":0.000006690619,"domain_scores_codex":[0.9948199,0.001338703,0.001742708,0.0007657398,0.0005352857,0.0007976323],"domain_scores_gemma":[0.9969131,0.0003896578,0.0009472379,0.0007729707,0.000650664,0.0003263969],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008260904,0.0004999372,0.0006463943,0.0002230611,0.0008392147,0.0009608447,0.002620646,0.000199011,0.9321283,0.00001770572,0.06076831,0.001014008],"study_design_scores_gemma":[0.005106159,0.002980941,0.0003909195,0.0001784716,0.0006991451,0.002128594,0.001910691,0.0000450428,0.9296771,0.00003281601,0.05676043,0.00008974435],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9600967,0.003201913,0.03189137,0.0003629127,0.0007405013,0.0007511667,0.00007023337,0.00002692286,0.002858306],"genre_scores_gemma":[0.9949431,0.0008479051,0.0006880416,0.001057734,0.0004341664,0.00001555563,0.00009327468,0.0001220145,0.001798193],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03484644,"threshold_uncertainty_score":0.9997191,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006219842120234684,"score_gpt":0.2522489308301076,"score_spread":0.2460290887098729,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}