{"id":"W4410975638","doi":"10.1164/rccm.202502-0512oc","title":"Long-Term Safety and Efficacy of Elexacaftor/Tezacaftor/Ivacaftor in Children ≥6 Years with Cystic Fibrosis and at Least One <i>F508del</i> Allele: A 192-Week, Phase 3, Open-Label Extension Study.","year":2025,"lang":"en","type":"article","venue":"PubMed","topic":"Cystic Fibrosis Research Advances","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"St. Michael's Hospital; BC Children's Hospital; University of Toronto","funders":"Vertex Pharmaceuticals","keywords":"Ivacaftor; Medicine; Cystic fibrosis; Term (time); Intensive care medicine; Internal medicine; Cystic fibrosis transmembrane conductance regulator","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001530676,0.0004652947,0.0009419749,0.0002376536,0.0002476675,0.0005664253,0.0004576951,0.0008537393,0.001917372],"category_scores_gemma":[0.001440931,0.0001902339,0.000916253,0.0002193979,0.0005311628,0.0007170451,0.0002674665,0.001983162,0.0004474097],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004794179,"about_ca_system_score_gemma":0.0008543667,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000961879,"about_ca_topic_score_gemma":0.001960272,"domain_scores_codex":[0.9995269,0.0001957549,0.00003232411,0.00006355244,0.00008245274,0.00009913152],"domain_scores_gemma":[0.9989791,0.0002016819,0.0003570222,0.00006808132,0.00006654423,0.0003276356],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.7205571,0.03321544,0.02969137,0.0009863796,0.00175042,0.0007975089,0.0003845115,0.0009969842,0.04779714,0.0002510148,0.004027026,0.1595452],"study_design_scores_gemma":[0.3008579,0.5663634,0.1170086,0.0002644525,0.001242694,0.001199678,0.000199357,0.000763745,0.006883953,0.0001734665,0.004991065,0.00005161052],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9942759,0.003163338,0.000191555,0.0001912821,0.0000414373,0.0003528261,0.0009376403,0.00003577426,0.000810244],"genre_scores_gemma":[0.9938505,0.001719289,0.0007265231,0.0004120927,0.00009014828,0.0005047063,0.001681219,0.00001526455,0.001000163],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001917372,"threshold_uncertainty_score":0.008095086,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02552615488847444,"score_gpt":0.3099675118481308,"score_spread":0.2844413569596564,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}