{"id":"W4410978508","doi":"10.1007/s00381-025-06864-8","title":"Sustained response to trametinib in an adult patient with neurofibromatosis type 1 and high-grade glioma","year":2025,"lang":"en","type":"article","venue":"Child s Nervous System","topic":"Neurofibromatosis and Schwannoma Cases","field":"Medicine","cited_by":2,"is_retracted":false,"has_abstract":false,"ca_institutions":"Hospital for Sick Children; Centre hospitalier universitaire de Québec; Montreal Children's Hospital; Centre Hospitalier Universitaire Sainte-Justine; McGill University; McGill University Health Centre; SickKids Foundation; University of Toronto; Université de Montréal; Université Laval","funders":"","keywords":"Trametinib; Neurofibromatosis; Glioma; Medicine; Neurofibromatosis type I; Neurofibromatosis type 2; Internal medicine; Oncology; Cancer research; Radiology; Biology; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002011433,0.0002872681,0.0006018217,0.0005382616,0.0001334083,0.00008235615,0.0001156713,0.0001045431,0.000003724847],"category_scores_gemma":[0.0002046897,0.0002221606,0.00004788881,0.001168028,0.00004938721,0.00008784506,0.00009205391,0.000177534,0.000008911494],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00009994333,"about_ca_system_score_gemma":0.0001376263,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001377914,"about_ca_topic_score_gemma":0.00004481133,"domain_scores_codex":[0.9978713,0.0003856962,0.0004833139,0.0005953393,0.0002803129,0.0003840312],"domain_scores_gemma":[0.9986171,0.0001640031,0.00008880117,0.0006211856,0.0002073962,0.0003015253],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.1606557,0.005099821,0.2688773,0.01298046,0.0007200562,0.0528031,0.01216344,0.0004384773,0.4232506,0.03325377,0.0116514,0.01810595],"study_design_scores_gemma":[0.01299446,0.01884105,0.860002,0.008140237,0.0003714275,0.009554457,0.0134721,0.0006066859,0.07287441,0.00003361712,0.00196021,0.001149348],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9939427,0.0001616747,0.00001154584,0.003457493,0.00017502,0.001179386,0.0000179032,0.0002034738,0.0008507794],"genre_scores_gemma":[0.998512,0.000002694768,0.0003513076,0.000859358,0.00003953048,0.00006670414,0.00001340822,0.0000471995,0.0001077833],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.5911247,"threshold_uncertainty_score":0.9059446,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007385896478875779,"score_gpt":0.2367312880183214,"score_spread":0.2293453915394457,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}