{"id":"W4410982365","doi":"10.1016/j.waojou.2025.101066","title":"Biomarker profile and disease burden associated with intermittent and long-term oral corticosteroid use in patients with severe asthma prior to biologic initiation in real-life (STAR)","year":2025,"lang":"en","type":"article","venue":"World Allergy Organization Journal","topic":"Asthma and respiratory diseases","field":"Medicine","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"Vancouver General Hospital; Kingston General Hospital; University of Alberta; Université Laval; Vancouver Coastal Health Research Institute; Emissions Reduction Alberta; Vancouver Coastal Health; Université de Sherbrooke; University of Toronto; Queen's University; Vancouver Hospital and Health Sciences Centre; University of British Columbia","funders":"Faculty of Medicine and Health, University of Sydney; Daiichi Sankyo Europe; Medical Research Council; Canadian Institutes of Health Research; Sanofi Genzyme; Directorate for Biological Sciences; Novartis Pharmaceuticals UK Limited; National Jewish Health; Humanitas Research Hospital; Lung Health Foundation; Grifols; Orient Europharma; King Fahad Medical City; British Columbia Lung Association; Teva Pharmaceutical Industries; Alfaisal University; Centro de Investigação em Tecnologias e Serviços de Saúde; Genentech; University of Alberta; Stiftung Universitätsmedizin Essen; Shire; Pontificia Universidad Javeriana; Universidad del Rosario; Vancouver Coastal Health Research Institute; Kuwait Foundation for the Advancement of Sciences; Universidade do Porto; AstraZeneca Australia; Novo Nordisk; Swedish Orphan Biovitrum; Universitetet i Bergen; Queen's University; Lunds Universitet; Queen's University Belfast; Shanghai Educational Development Foundation; Taichung Veterans General Hospital; Asthma Australia; Bispebjerg Hospital; University of New South Wales; Singapore General Hospital; Skånes universitetssjukhus; Erasmus Medisch Centrum; Thoracic Society of Australia and New Zealand; Moderna; Allergy Therapeutics; AstraZeneca; Insmed; University of Aberdeen; King's College London; Michael Smith Health Research BC; Catholic University of Korea; Canadian Lung Association; University of Toronto; Macquarie University; College of Medicine, Catholic University of Korea; Shionogi; Hunter Medical Research Institute; Universidad Nacional de Rosario; American Thoracic Society; Optimum Patient Care; Haukeland Universitetssjukehus; Universiteit Gent; Chiesi Farmaceutici; GlaxoSmithKline; Cerecor; Pfizer; Universidad de Buenos Aires; Monash University; United Therapeutics Corporation; Horizon Therapeutics; National Institute for Health and Care Research; University of Queensland; Tays; Western Sydney University; Háskóli Íslands; Landspítali Háskólasjúkrahús; Kindai University; National and Kapodistrian University of Athens; Seoul St. Mary's Hospital, Catholic University of Korea; Kanazawa University; UCB Pharma; Cystic Fibrosis Foundation; Mylan; Instituto de Seguriidad y Servicios Sociales de los Trabadores del Estado; Canadian Thoracic Society; Regeneron Pharmaceuticals; Universitair Ziekenhuis Gent; Government of Ontario; Humanitas University; Uniwersytet Łódzki; Helsingin Yliopisto; Université Laval; Seqirus; Bristol-Myers Squibb; European Respiratory Society; Sanofi; CSL Behring; Glenmark Pharmaceuticals; Danone; Gilead Sciences; Celltrion Healthcare; Università degli Studi di Torino; Covis Pharma; University of British Columbia; Eli Lilly and Company; Celltrion; Incyte; Curtin University of Technology; Taipei Veterans General Hospital; Amgen","keywords":"Medicine; Asthma; Biomarker; Corticosteroid; Disease; Intensive care medicine; Pediatrics; Internal medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009125084,0.0001665528,0.0002368152,0.0004826501,0.00009728764,0.00009568357,0.00004649301,0.00004605636,0.0001069529],"category_scores_gemma":[0.0005058911,0.0001154835,0.00001278567,0.0008661909,0.00005412176,0.0002287652,0.00005712537,0.0001482783,0.000001478421],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001539752,"about_ca_system_score_gemma":0.0003098856,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000007462004,"about_ca_topic_score_gemma":0.0004709924,"domain_scores_codex":[0.9989126,0.0001274755,0.0003350173,0.0002426315,0.0001922766,0.0001900034],"domain_scores_gemma":[0.9990129,0.00003634849,0.0001629827,0.00009875238,0.0003202966,0.0003686949],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001327338,0.00026432,0.9950367,0.00002774672,0.00007176118,0.0001059972,0.0001443754,0.00003172763,0.00005946757,0.000008723029,0.0001191409,0.002802676],"study_design_scores_gemma":[0.004714039,0.0003262868,0.993671,0.0009018753,0.00003607176,0.000007912658,0.00007756947,0.00005831848,0.000007934001,0.000002890201,0.00005359573,0.0001425219],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9983946,0.00006680531,0.000152659,0.000712085,0.00004453096,0.0005737685,0.00001326783,0.00002401143,0.00001828607],"genre_scores_gemma":[0.9985116,0.00003356998,0.0000801338,0.000881895,0.00002131285,0.0000109549,0.0001536206,0.00002239778,0.0002845532],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003386701,"threshold_uncertainty_score":0.4709282,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01196698282418923,"score_gpt":0.2429756903460767,"score_spread":0.2310087075218875,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). 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