{"id":"W4410982365","doi":"10.1016/j.waojou.2025.101066","title":"Biomarker profile and disease burden associated with intermittent and long-term oral corticosteroid use in patients with severe asthma prior to biologic initiation in real-life (STAR)","year":2025,"lang":"en","type":"article","venue":"World Allergy Organization Journal","topic":"Asthma and respiratory diseases","field":"Medicine","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"Vancouver General Hospital; Kingston General Hospital; University of Alberta; Université Laval; Vancouver Coastal Health Research Institute; Emissions Reduction Alberta; Vancouver Coastal Health; Université de Sherbrooke; University of Toronto; Queen's University; Vancouver Hospital and Health Sciences Centre; University of British Columbia","funders":"Faculty of Medicine and Health, University of Sydney; Daiichi Sankyo Europe; Medical Research Council; Canadian Institutes of Health Research; Sanofi Genzyme; Directorate for Biological Sciences; Novartis Pharmaceuticals UK Limited; National Jewish Health; Humanitas Research Hospital; Lung Health Foundation; Grifols; Orient Europharma; King Fahad Medical City; British Columbia Lung Association; Teva Pharmaceutical Industries; Alfaisal University; Centro de Investigação em Tecnologias e Serviços de Saúde; Genentech; University of Alberta; Stiftung Universitätsmedizin Essen; Shire; Pontificia Universidad Javeriana; Universidad del Rosario; Vancouver Coastal Health Research Institute; Kuwait Foundation for the Advancement of Sciences; Universidade do Porto; AstraZeneca Australia; Novo Nordisk; Swedish Orphan Biovitrum; Universitetet i Bergen; Queen's University; Lunds Universitet; Queen's University Belfast; Shanghai Educational Development Foundation; Taichung Veterans General Hospital; Asthma Australia; Bispebjerg Hospital; University of New South Wales; Singapore General Hospital; Skånes universitetssjukhus; Erasmus Medisch Centrum; Thoracic Society of Australia and New Zealand; Moderna; Allergy Therapeutics; AstraZeneca; Insmed; University of Aberdeen; King's College London; Michael Smith Health Research BC; Catholic University of Korea; Canadian Lung Association; University of Toronto; Macquarie University; College of Medicine, Catholic University of Korea; Shionogi; Hunter Medical Research Institute; Universidad Nacional de Rosario; American Thoracic Society; Optimum Patient Care; Haukeland Universitetssjukehus; Universiteit Gent; Chiesi Farmaceutici; GlaxoSmithKline; Cerecor; Pfizer; Universidad de Buenos Aires; Monash University; United Therapeutics Corporation; Horizon Therapeutics; National Institute for Health and Care Research; University of Queensland; Tays; Western Sydney University; Háskóli Íslands; Landspítali Háskólasjúkrahús; Kindai University; National and Kapodistrian University of Athens; Seoul St. Mary's Hospital, Catholic University of Korea; Kanazawa University; UCB Pharma; Cystic Fibrosis Foundation; Mylan; Instituto de Seguriidad y Servicios Sociales de los Trabadores del Estado; Canadian Thoracic Society; Regeneron Pharmaceuticals; Universitair Ziekenhuis Gent; Government of Ontario; Humanitas University; Uniwersytet Łódzki; Helsingin Yliopisto; Université Laval; Seqirus; Bristol-Myers Squibb; European Respiratory Society; Sanofi; CSL Behring; Glenmark Pharmaceuticals; Danone; Gilead Sciences; Celltrion Healthcare; Università degli Studi di Torino; Covis Pharma; University of British Columbia; Eli Lilly and Company; Celltrion; Incyte; Curtin University of Technology; Taipei Veterans General Hospital; Amgen","keywords":"Medicine; Asthma; Biomarker; Corticosteroid; Disease; Intensive care medicine; Pediatrics; Internal medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0009518802,0.0002475829,0.0003553766,0.0006787925,0.0003113514,0.0008683102,0.0004130264,0.0004489314,0.0009797482],"category_scores_gemma":[0.002100294,0.0002073383,0.0006558744,0.001223658,0.0002343927,0.0004457773,0.0006855772,0.0005440043,0.0002446864],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000330399,"about_ca_system_score_gemma":0.0003575488,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00301191,"about_ca_topic_score_gemma":0.00426998,"domain_scores_codex":[0.9991285,0.000214492,0.000148169,0.0002625525,0.0001308282,0.0001155451],"domain_scores_gemma":[0.9968421,0.0002662825,0.002141137,0.0002814653,0.000219271,0.0002497643],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.00004967409,0.000008008364,0.9995247,0.000006028013,0.00002558179,0.00001416711,0.00001570507,0.00001877313,0.00005945641,0.00000544367,0.00002784912,0.0002444587],"study_design_scores_gemma":[0.000002448515,0.00005392669,0.9995536,0.0000047395,0.00001620987,0.000126579,0.00006291917,0.00006725291,0.00002864602,0.000007676888,0.00007412807,0.00000182931],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9979103,0.00033313,0.00008802555,0.00003719066,0.00000470305,0.000009582637,0.001337131,0.000003546753,0.0002763036],"genre_scores_gemma":[0.9984943,0.00008460979,0.000109415,0.00002245021,0.000006941327,0.00001314961,0.0011958,0.000001360463,0.00007208307],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00301191,"threshold_uncertainty_score":0.005988777,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01196698282418923,"score_gpt":0.2429756903460767,"score_spread":0.2310087075218875,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). 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