{"id":"W4410995022","doi":"10.1016/j.dmpk.2025.101159","title":"Intra-patient variation in CYP2D6 activity over time assessed using the dietary biomarker solanidine in breast cancer patients on tamoxifen","year":2025,"lang":"en","type":"article","venue":"Drug Metabolism and Pharmacokinetics","topic":"Pharmacogenetics and Drug Metabolism","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"Western University; London Health Sciences Centre","funders":"","keywords":"Tamoxifen; Medicine; Breast cancer; Biomarker; Oncology; CYP2D6; Internal medicine; Endocrinology; Cancer; Biology; Metabolism; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0009704789,0.0005341755,0.0006149785,0.0005334658,0.0002550839,0.00006817685,0.0003915226,0.0002664424,0.0005784322],"category_scores_gemma":[0.00004650876,0.000436423,0.000115975,0.00106701,0.0001910243,0.0002229609,0.0002705358,0.001127923,0.00001279092],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001240733,"about_ca_system_score_gemma":0.0001595445,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005837191,"about_ca_topic_score_gemma":0.00004436438,"domain_scores_codex":[0.9963099,0.001236599,0.0006915709,0.0006628887,0.0003612715,0.0007377424],"domain_scores_gemma":[0.9985835,0.00048783,0.0002769213,0.0002872283,0.000151302,0.0002132045],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.003658311,0.004219355,0.09857014,0.0001899624,0.0006603153,0.0000461501,0.003685316,0.01314215,0.7305436,0.0003930746,0.006653927,0.1382378],"study_design_scores_gemma":[0.007348453,0.00002032158,0.7943604,0.00007187945,0.0006246085,0.000003607931,0.00002620809,0.1310827,0.03639476,0.0004111301,0.02907868,0.0005773007],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9897916,0.002916028,0.00002765268,0.001806764,0.002856999,0.001034641,0.0006957453,0.00004051138,0.0008300674],"genre_scores_gemma":[0.9901426,0.003882508,0.00006032876,0.005307366,0.0002690461,0.0001144749,0.00003662827,0.00004472356,0.0001423402],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.6957902,"threshold_uncertainty_score":0.9998087,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04173498236393011,"score_gpt":0.3835974584192779,"score_spread":0.3418624760553479,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}