{"id":"W4410995952","doi":"10.1177/20543581251348187","title":"The Aldosterone Blockade for Health Improvement Evaluation in End-Stage Renal Disease (ACHIEVE) Trial: Rationale and Clinical Research Protocol","year":2025,"lang":"en","type":"article","venue":"Canadian Journal of Kidney Health and Disease","topic":"Hormonal Regulation and Hypertension","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"St. Michael's Hospital; Nova Scotia Health Authority; Dalhousie University; Hamilton Health Sciences; St. Joseph's Hospital; Impact; McMaster University; University of Alberta; Population Health Research Institute","funders":"Medical Research Future Fund; Faculty of Medicine, Dalhousie University; Canadian Institutes of Health Research; Population Health Research Institute; Health Research Council of New Zealand; British Heart Foundation","keywords":"Medicine; Blockade; End stage renal disease; Aldosterone; Kidney disease; Stage (stratigraphy); Disease; Clinical trial; Intensive care medicine; Internal medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.01705039,0.004678844,0.006016734,0.001569371,0.002474758,0.003338869,0.002750486,0.004250632,0.04009017],"category_scores_gemma":[0.01323211,0.002093556,0.003309242,0.00299992,0.002041518,0.002856385,0.001733417,0.006032804,0.01034012],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.003012793,"about_ca_system_score_gemma":0.01096479,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001762901,"about_ca_topic_score_gemma":0.00408552,"domain_scores_codex":[0.9878674,0.007875236,0.001175258,0.00123879,0.0009235043,0.0009198175],"domain_scores_gemma":[0.995804,0.0008494389,0.0009053551,0.0005314097,0.001143541,0.0007662692],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"not_applicable","study_design_scores_codex":[0.7743636,0.01285712,0.004816979,0.04331001,0.00404315,0.0007183604,0.0008209922,0.002892196,0.003665393,0.01143334,0.07907205,0.06200671],"study_design_scores_gemma":[0.8544364,0.02129454,0.009921091,0.009422362,0.002831338,0.0002796858,0.0003847364,0.003012646,0.0009521962,0.009027899,0.08822712,0.0002100285],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"protocol","genre_gemma":"protocol","genre_scores_codex":[0.003564643,0.001503548,0.002643097,0.0006788265,0.0003735626,0.9822173,0.006036744,0.0001208376,0.002861416],"genre_scores_gemma":[0.004444149,0.0005472298,0.002973483,0.0004338773,0.00009526567,0.9893819,0.001216508,0.00001274499,0.0008947586],"genre_candidate":"protocol","genre_consensus":"protocol","teacher_disagreement_score":0.04009017,"threshold_uncertainty_score":0.134115,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1359682169278129,"score_gpt":0.4912333682943815,"score_spread":0.3552651513665686,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}