{"id":"W4410996168","doi":"10.1016/j.dmpk.2025.101163","title":"An evaluation of CYP and non-CYP reaction phenotyping study trends from 2000-2023: A cro perspective","year":2025,"lang":"en","type":"article","venue":"Drug Metabolism and Pharmacokinetics","topic":"Metabolomics and Mass Spectrometry Studies","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"Yorkville University","funders":"","keywords":"Perspective (graphical); Pharmacology; Chemistry; Computational biology; Medicine; Biology; Computer science","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006196637,0.0002128298,0.0003315794,0.0002011096,0.00012236,0.00003455663,0.0001152188,0.00006764679,0.00003584392],"category_scores_gemma":[0.00006162724,0.0002024137,0.00005181699,0.0002816618,0.00008688674,0.0000132173,0.000117223,0.0001135793,3.58658e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001691833,"about_ca_system_score_gemma":0.00006533943,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005479239,"about_ca_topic_score_gemma":0.000112378,"domain_scores_codex":[0.9986293,0.0002050648,0.0002726568,0.0004903214,0.0002251698,0.0001774401],"domain_scores_gemma":[0.9991561,0.00002378879,0.0001317561,0.0002738598,0.0003439669,0.00007048345],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0002901248,0.0004805116,0.004188314,0.00002060652,0.0007181048,8.26685e-7,0.002588251,0.00004256022,0.9459218,0.0004064415,0.001111766,0.04423068],"study_design_scores_gemma":[0.01116261,0.0003281997,0.5089787,0.0000335871,0.00490543,0.000003003083,0.0143071,0.008064933,0.4158438,0.002202111,0.0333478,0.0008228134],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9727053,0.02269995,0.0002322919,0.0001256657,0.0004231562,0.0003104276,0.0001073002,0.000008234197,0.003387683],"genre_scores_gemma":[0.9951354,0.003558861,0.0003619462,0.0001022618,0.000305912,0.00003625642,0.00005758495,0.00001478336,0.0004269931],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.5300781,"threshold_uncertainty_score":0.8254191,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01388019250880445,"score_gpt":0.3279601522160859,"score_spread":0.3140799597072814,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}