{"id":"W4410998031","doi":"10.1200/jco-25-00744","title":"Isatuximab Subcutaneous by On-Body Injector Versus Isatuximab Intravenous Plus Pomalidomide and Dexamethasone in Relapsed/Refractory Multiple Myeloma: Phase III IRAKLIA Study","year":2025,"lang":"en","type":"article","venue":"Journal of Clinical Oncology","topic":"Multiple Myeloma Research and Treatments","field":"Medicine","cited_by":12,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hôpital Maisonneuve-Rosemont","funders":"","keywords":"Medicine; Pomalidomide; Adverse effect; Dexamethasone; Refractory (planetary science); Internal medicine; Clinical endpoint; Multiple myeloma; Gastroenterology; Randomized controlled trial; Lenalidomide","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002215085,0.001041398,0.002467844,0.0003549943,0.0002438914,0.00109494,0.00100655,0.000721195,0.003409713],"category_scores_gemma":[0.00151766,0.0004166599,0.001393206,0.0004986778,0.0007629523,0.0005812828,0.0003892497,0.003133797,0.0008171838],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008817884,"about_ca_system_score_gemma":0.001608094,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006465664,"about_ca_topic_score_gemma":0.001483838,"domain_scores_codex":[0.9992164,0.0004653796,0.00003377229,0.00009849133,0.00005875804,0.0001271521],"domain_scores_gemma":[0.9985751,0.0002314938,0.0004099642,0.0001147596,0.00007207337,0.0005966902],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.8928882,0.02444608,0.004529163,0.0006473277,0.001171613,0.00006647459,0.0001419048,0.001221775,0.00898489,0.0002148687,0.002689097,0.06299865],"study_design_scores_gemma":[0.7165172,0.2660555,0.01055537,0.00006575544,0.001093726,0.000146361,0.00005907019,0.001358475,0.001651189,0.0001621058,0.002309635,0.00002572202],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9904581,0.002895411,0.0005007783,0.0005489202,0.0001643472,0.001923938,0.0008240477,0.00009242187,0.00259188],"genre_scores_gemma":[0.9912018,0.00162702,0.001183832,0.00112,0.0003664155,0.001609435,0.001103243,0.00003209881,0.001756143],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003409713,"threshold_uncertainty_score":0.01171464,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08940169969264583,"score_gpt":0.4717100872894226,"score_spread":0.3823083875967768,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}