{"id":"W4411000674","doi":"10.1007/s13555-025-01453-8","title":"Real-World Effectiveness and Safety of Dupilumab, Tralokinumab, and Upadacitinib in Patients with Atopic Dermatitis: A 52-Week International, Multicenter Retrospective Cohort Study","year":2025,"lang":"en","type":"article","venue":"Dermatology and Therapy","topic":"Dermatology and Skin Diseases","field":"Medicine","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"SKiN Health; University of Calgary; Probity Medical Research; Health Sciences Centre; Women's College Hospital; University of Toronto; Sunnybrook Health Science Centre","funders":"Sanofi Genzyme; LEO Pharma; Galderma; Sanofi; Amgen; Pfizer; Eli Lilly and Company; Bristol-Myers Squibb","keywords":"Dupilumab; Atopic dermatitis; Medicine; Retrospective cohort study; Multicenter study; Cohort; Dermatology; Internal medicine; Randomized controlled trial","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00243287,0.0004134976,0.000720322,0.0005254491,0.0003887345,0.000913508,0.0004324641,0.0004759582,0.001100607],"category_scores_gemma":[0.002724362,0.0002642373,0.0009274746,0.0007539231,0.0003323054,0.0006728541,0.0003808436,0.0006497908,0.000277748],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004965857,"about_ca_system_score_gemma":0.0002685855,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007222821,"about_ca_topic_score_gemma":0.0006437285,"domain_scores_codex":[0.9986778,0.0003948123,0.0001806806,0.000386756,0.0002240618,0.0001358942],"domain_scores_gemma":[0.9962665,0.0005696162,0.00219826,0.0003708059,0.0002807322,0.000314119],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.007631685,0.0004026019,0.985157,0.0001165509,0.0006851683,0.0001627493,0.0001374946,0.0001495056,0.0007367223,0.00002306361,0.0001715156,0.004625936],"study_design_scores_gemma":[0.0004207048,0.005068062,0.9910817,0.00003875553,0.0006285664,0.001018374,0.0001830753,0.0003638609,0.0004295568,0.00002201445,0.0007259065,0.00001936051],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9985447,0.0007229464,0.00007015996,0.00001551956,0.000004163257,0.00004040664,0.0004128974,0.000002096766,0.000187074],"genre_scores_gemma":[0.9990525,0.0001413867,0.00008514955,0.00002468573,0.00001286546,0.00003661307,0.0005726645,0.000001771333,0.0000724567],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00243287,"threshold_uncertainty_score":0.01286638,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005650236608070343,"score_gpt":0.2680949643653479,"score_spread":0.2624447277572775,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}