{"id":"W4411000674","doi":"10.1007/s13555-025-01453-8","title":"Real-World Effectiveness and Safety of Dupilumab, Tralokinumab, and Upadacitinib in Patients with Atopic Dermatitis: A 52-Week International, Multicenter Retrospective Cohort Study","year":2025,"lang":"en","type":"article","venue":"Dermatology and Therapy","topic":"Dermatology and Skin Diseases","field":"Medicine","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"SKiN Health; University of Calgary; Probity Medical Research; Health Sciences Centre; Women's College Hospital; University of Toronto; Sunnybrook Health Science Centre","funders":"Sanofi Genzyme; LEO Pharma; Galderma; Sanofi; Amgen; Pfizer; Eli Lilly and Company; Bristol-Myers Squibb","keywords":"Dupilumab; Atopic dermatitis; Medicine; Retrospective cohort study; Multicenter study; Cohort; Dermatology; Internal medicine; Randomized controlled trial","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001060661,0.0001636515,0.0005554592,0.0002463994,0.00007470318,0.00001000452,0.00005179716,0.000087254,0.00002260751],"category_scores_gemma":[0.00003064705,0.0001301246,0.00002430386,0.0001462036,0.0003138237,0.0001037927,0.00003452841,0.0001545951,5.015647e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002615881,"about_ca_system_score_gemma":0.00003380891,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000904622,"about_ca_topic_score_gemma":0.0001309941,"domain_scores_codex":[0.9989352,0.0002229604,0.0002890266,0.0002976183,0.0001049355,0.0001502766],"domain_scores_gemma":[0.9994113,0.000207583,0.00008456346,0.0001477464,0.00009811495,0.00005066453],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.002141851,0.0009635857,0.9938988,0.0001171923,0.0005318075,0.00008562801,0.0005262254,1.841266e-7,0.000004379473,0.0005214611,0.00005022779,0.001158645],"study_design_scores_gemma":[0.0174188,0.0001656606,0.981177,0.0002020939,0.00008294849,0.00005056829,0.0001660072,0.00002481415,0.0001341077,0.0003192566,0.0001578087,0.0001009584],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.99657,0.0006350289,0.0000200288,0.0003605424,0.00008359038,0.001233318,0.00001684547,0.00002096755,0.001059692],"genre_scores_gemma":[0.9986122,0.0008604486,0.00003901212,0.0003374558,0.000004388349,0.00008136479,0.00002568611,0.000008777244,0.00003065407],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01527695,"threshold_uncertainty_score":0.5306325,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005650236608070343,"score_gpt":0.2680949643653479,"score_spread":0.2624447277572775,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}