{"id":"W4411001306","doi":"10.1101/2025.06.02.657522","title":"Purinergic receptor activation rectifies autism-associated endothelial dysfunction","year":2025,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Adenosine and Purinergic Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Ottawa; Ottawa Hospital","funders":"Canadian Institutes of Health Research","keywords":"Purinergic receptor; Autism; Endothelial dysfunction; Neuroscience; Receptor; Medicine; Psychology; Internal medicine; Psychiatry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001619446,0.0002830134,0.0002482296,0.0002776384,0.000140783,0.0002688717,0.000176382,0.0004360657,0.003149142],"category_scores_gemma":[0.0001566735,0.0001245329,0.0001785694,0.0001059484,0.000259337,0.0001481201,0.0003277896,0.0006085447,0.0005817655],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001539524,"about_ca_system_score_gemma":0.0001168097,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002298518,"about_ca_topic_score_gemma":0.0002642943,"domain_scores_codex":[0.9999086,0.00001381395,0.000008246051,0.00002069584,0.00002731763,0.00002136518],"domain_scores_gemma":[0.9999144,0.00001330969,0.00002565828,0.0000136674,0.000008857536,0.00002411865],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001908225,0.00002213735,0.0004184373,0.00005241652,0.000007602721,0.0006230492,0.00001589855,0.00005969508,0.9948143,0.0002297846,0.0003030017,0.003263029],"study_design_scores_gemma":[0.0001010695,0.0004228009,0.02651607,0.00003169157,0.00003463578,0.006408425,0.0001179986,0.00177499,0.9504603,0.000773075,0.01334531,0.00001357857],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9841177,0.002733795,0.005938615,0.000691529,0.0001727139,0.00002977629,0.0008395376,0.000265636,0.005210626],"genre_scores_gemma":[0.9907425,0.001210344,0.002313227,0.000149507,0.00003976176,0.00003941168,0.000472957,0.00003856651,0.004993659],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003149142,"threshold_uncertainty_score":0.01053494,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00963129706549801,"score_gpt":0.2148216824954077,"score_spread":0.2051903854299097,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}