{"id":"W4411002619","doi":"10.1021/acscentsci.5c00332","title":"Asymmetric Total Synthesis of 4,9,10-Trihydroxyguaia-11(13)en-12,6-olide and Discovery of Its Anticancer Activity against Atypical Teratoid Rhabdoid Tumor","year":2025,"lang":"en","type":"article","venue":"ACS Central Science","topic":"Microbial Natural Products and Biosynthesis","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Division of Chemistry; National Institute of Allergy and Infectious Diseases; Institute for Basic Science; Korea Health Industry Development Institute; North Carolina State University; National Science Foundation Graduate Research Fellowship Program; Canadian Institute for Advanced Research; Duke University; University of North Carolina at Chapel Hill; National Institutes of Health; National Science Foundation","keywords":"Chemistry; Cancer research; Stereochemistry; Computational biology; Medicine; Biology","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000132726,0.0004936146,0.0002586438,0.0004262268,0.0001670655,0.0002095889,0.0003335092,0.0002232169,0.003491451],"category_scores_gemma":[0.00009466714,0.0001550938,0.0002092184,0.0003933728,0.0001473494,0.000368421,0.0002932408,0.0004594099,0.00144636],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002134349,"about_ca_system_score_gemma":0.0004076462,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004589403,"about_ca_topic_score_gemma":0.00120293,"domain_scores_codex":[0.9999249,0.000007191106,0.000005699853,0.00001601954,0.00002204913,0.00002406865],"domain_scores_gemma":[0.9999607,0.00000409343,0.000006849598,0.000006268006,0.00000914272,0.00001297115],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008939933,0.00005053028,0.00008690501,0.00015714,0.00001249957,0.0004513794,0.00005896995,0.0005702559,0.9844964,0.001172439,0.0005093318,0.01234472],"study_design_scores_gemma":[0.00003338777,0.0002883413,0.0006961393,0.00001371809,0.00002123225,0.0002800497,0.0000389403,0.001336272,0.98131,0.0003939257,0.01557003,0.00001792606],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8519081,0.006966713,0.06937919,0.0006960524,0.0003107873,0.0004515397,0.005734347,0.001341301,0.06321197],"genre_scores_gemma":[0.9440391,0.006386503,0.03092825,0.0002290771,0.00004931049,0.0001920618,0.002409731,0.0001542084,0.0156118],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003491451,"threshold_uncertainty_score":0.01168013,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006664696961360171,"score_gpt":0.2458090599098273,"score_spread":0.2391443629484671,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}