{"id":"W4411009277","doi":"10.1016/j.jcjo.2025.05.014","title":"Association between intravitreal anti-vascular endothelial growth factor agents and hypertension: a meta-analysis","year":2025,"lang":"en","type":"article","venue":"Canadian Journal of Ophthalmology","topic":"Retinal Diseases and Treatments","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"St. Michael's Hospital; Sunnybrook Health Science Centre; Dalhousie University; McMaster University; University of Toronto","funders":"Foundation Fighting Blindness; Physicians' Services Incorporated Foundation","keywords":"Medicine; Aflibercept; Ranibizumab; Bevacizumab; Relative risk; Adverse effect; Meta-analysis; Internal medicine; Confidence interval; Randomized controlled trial; Risk factor; Subgroup analysis; Ocular hypertension; Vascular endothelial growth factor; VEGF receptors; Surgery; Intraocular pressure; Chemotherapy","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.01186076,0.002655848,0.0151196,0.004201138,0.0005792817,0.002947279,0.001892999,0.002583868,0.003429035],"category_scores_gemma":[0.02629799,0.001643328,0.04222906,0.004645555,0.0005428458,0.001297271,0.001083353,0.002070687,0.0003219205],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001687138,"about_ca_system_score_gemma":0.001710875,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.006494518,"about_ca_topic_score_gemma":0.009347179,"domain_scores_codex":[0.9892965,0.006320094,0.001903072,0.001273143,0.000865169,0.0003420179],"domain_scores_gemma":[0.9787911,0.0165689,0.002748033,0.0006446219,0.000930427,0.0003168671],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"meta_analysis","study_design_gemma":"meta_analysis","study_design_scores_codex":[0.005105434,0.00003041709,0.006158715,0.04677273,0.9373557,0.00009707196,0.00002629629,0.0004619452,0.000165461,0.00005662692,0.0002589423,0.003510768],"study_design_scores_gemma":[0.001030112,0.0002668516,0.003850531,0.00293309,0.9909861,0.00006264302,0.00001537839,0.0002757481,0.00008042364,0.00009536956,0.0003915094,0.0000121957],"study_design_candidate":"meta_analysis","study_design_consensus":"meta_analysis","genre_codex":"review","genre_gemma":"empirical","genre_scores_codex":[0.02585481,0.9708867,0.001127389,0.0003169921,0.0003751374,0.0002662817,0.0006840065,0.00005032293,0.0004382934],"genre_scores_gemma":[0.5788527,0.4128144,0.003618648,0.00112476,0.000751371,0.001000016,0.001011542,0.00006474808,0.0007619057],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.0151196,"threshold_uncertainty_score":0.06272644,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05390702517743107,"score_gpt":0.3046534512449998,"score_spread":0.2507464260675687,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}