{"id":"W4411014350","doi":"10.1101/2025.06.03.25328899","title":"Vascular risk factors mediate the relationship between education and white matter hyperintensities","year":2025,"lang":"en","type":"preprint","venue":"medRxiv","topic":"Dementia and Cognitive Impairment Research","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Carleton University; Université de Montréal; McGill University; Douglas Mental Health University Institute; Douglas College","funders":"Canadian Institutes of Health Research; National Institute on Aging; National Institutes of Health","keywords":"Hyperintensity; White matter; Psychology; White (mutation); Medicine; Magnetic resonance imaging; Chemistry; Radiology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001351541,0.000520309,0.0003903182,0.0005277057,0.0002612815,0.001102542,0.0004771563,0.0004330885,0.01422192],"category_scores_gemma":[0.007783367,0.0002577234,0.0007567804,0.000487292,0.000305839,0.0004551356,0.0007170738,0.0006483359,0.0005890185],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002993,"about_ca_system_score_gemma":0.0009019171,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.006619922,"about_ca_topic_score_gemma":0.006808109,"domain_scores_codex":[0.9995042,0.0002274421,0.00003175301,0.00007023274,0.00005237553,0.000114017],"domain_scores_gemma":[0.9967492,0.001618028,0.0008624411,0.0002572365,0.0002109272,0.0003022872],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0004613888,0.0002420687,0.9820633,0.0001117456,0.000691137,0.0001755274,0.0002088015,0.0002056392,0.0003752635,0.0004794211,0.0008471272,0.01413859],"study_design_scores_gemma":[0.00005748697,0.0001165178,0.9953237,0.00009772886,0.0003695121,0.0001540782,0.0002220262,0.0004504759,0.0004623084,0.001501506,0.001237838,0.000006778974],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9880447,0.002756975,0.0007436379,0.00191877,0.00005482758,0.00001969992,0.00153386,0.00003829583,0.004889342],"genre_scores_gemma":[0.9963045,0.0008439356,0.0005204612,0.0001312505,0.00007636949,0.00001758099,0.0006057608,0.00000473221,0.001495469],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01422192,"threshold_uncertainty_score":0.04757714,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03667114267236367,"score_gpt":0.3235187136403609,"score_spread":0.2868475709679972,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}