{"id":"W4411015159","doi":"10.1016/j.eclinm.2025.103283","title":"Incident cytopenia and risk of subsequent myeloid neoplasm in age-related clonal hematopoiesis: a multi-biobank case-control study","year":2025,"lang":"en","type":"article","venue":"EClinicalMedicine","topic":"Acute Myeloid Leukemia Research","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Queen's University","funders":"National Institute of Diabetes and Digestive and Kidney Diseases; Foundation for the National Institutes of Health; American Federation for Aging Research; American Society of Hematology; Edward P. Evans Foundation; Alexander and Margaret Stewart Trust; National Cancer Institute; National Institutes of Health; Pew Charitable Trusts; Burroughs Wellcome Fund; ASH Foundation; National Center for Advancing Translational Sciences","keywords":"Medicine; Cytopenia; Biobank; Oncology; Internal medicine; Bioinformatics; Bone marrow","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.004450635,0.0003758625,0.001702554,0.0006611781,0.0001047148,0.0000165872,0.0002635894,0.0003412472,0.0002065095],"category_scores_gemma":[0.005809932,0.0002891936,0.0001769034,0.001002271,0.0007100274,0.00007871688,0.0003021399,0.001600081,0.00002859664],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003641106,"about_ca_system_score_gemma":0.0006632012,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002639611,"about_ca_topic_score_gemma":0.002178617,"domain_scores_codex":[0.9951866,0.0006860921,0.002100215,0.0007939717,0.0006588406,0.000574299],"domain_scores_gemma":[0.9957335,0.002397442,0.0003810145,0.0008564342,0.0002572695,0.0003743122],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.00194848,0.001861018,0.9648616,0.0002559074,0.001116485,0.02064438,0.001408855,0.0000187884,0.0008660075,0.0001066632,0.0007620903,0.006149713],"study_design_scores_gemma":[0.04736992,0.001670627,0.9413542,0.000735788,0.00110232,0.001308524,0.002343553,0.003310135,0.0001745441,0.0001986747,0.0002166539,0.0002151286],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9909878,0.002004328,0.0002004688,0.003153383,0.0002704785,0.002785911,0.00004034779,0.00006915241,0.0004881582],"genre_scores_gemma":[0.9960955,0.0007138705,0.0009972084,0.0006669309,0.0001090677,0.0001262935,0.00001428301,0.0000371333,0.001239724],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.04542144,"threshold_uncertainty_score":0.999956,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02690128170703804,"score_gpt":0.3556942714960155,"score_spread":0.3287929897889775,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}