{"id":"W4411017094","doi":"10.1016/j.tjpad.2025.100205","title":"Utility of plasma GFAP as a secondary endpoint for clinical trials in Alzheimer’s disease","year":2025,"lang":"en","type":"article","venue":"The Journal of Prevention of Alzheimer s Disease","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":9,"is_retracted":false,"has_abstract":true,"ca_institutions":"Centre Intégré Universitaire de Santé et de Services Sociaux du Centre-Sud-de-l'Île-de-Montréal; McGill University; Douglas Mental Health University Institute","funders":"H2020 Marie Skłodowska-Curie Actions; Fonds de Recherche du Québec - Santé; Horizon 2020 Framework Programme; Olav Thon Stiftelsen; Emil och Wera Cornells Stiftelse; Instituto Serrapilheira; National Research Foundation of Korea; Ministry of Science and ICT, South Korea; Ministry of Health and Welfare; Conselho Nacional de Desenvolvimento Científico e Tecnológico; University College London; Korea Health Industry Development Institute; National Institute on Aging; National Institute for Health and Care Research; EU Joint Programme – Neurodegenerative Disease Research; Alzheimer's Association; Stiftelsen för Gamla Tjänarinnor; Familjen Erling-Perssons Stiftelse; Korea Disease Control and Prevention Agency; Vetenskapsrådet; Fundação de Amparo à Pesquisa do Estado do Rio Grande do Sul; National Academy of Neuropsychology; Alzheimerfonden; Weston Brain Institute; Alzheimer's Drug Discovery Foundation; Canadian Institutes of Health Research; Instituto de Ciência e Tecnologia de Nanomateriais de Carbono","keywords":"Disease; Alzheimer's disease; Clinical trial; Clinical endpoint; Medicine; Endpoint Determination; Pathology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.008999929,0.0002745446,0.001471336,0.0004429637,0.00007896928,0.00001474522,0.0003454669,0.0001017296,0.0007433771],"category_scores_gemma":[0.004021195,0.000183941,0.001901766,0.0003394577,0.000398991,0.0002337269,0.0001225778,0.0004141758,0.000008875974],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002796376,"about_ca_system_score_gemma":0.003768719,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002104035,"about_ca_topic_score_gemma":0.000005531142,"domain_scores_codex":[0.9929318,0.002518314,0.003169524,0.0002773207,0.0007543202,0.0003486764],"domain_scores_gemma":[0.9939253,0.002041262,0.001734,0.0006634956,0.0006863232,0.0009496572],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"observational","study_design_scores_codex":[0.3309721,0.0317145,0.2027718,0.001702163,0.1477909,0.0005832171,0.0003772105,0.00005582583,0.0002103677,0.002996196,0.02178157,0.2590441],"study_design_scores_gemma":[0.01940823,0.001447664,0.905761,0.001498217,0.0486216,0.00001194288,0.0002925293,0.0006355085,0.002971196,0.01835281,0.0007956973,0.0002035973],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8337387,0.156353,0.0004168171,0.003462708,0.0005000532,0.003964729,0.0006763096,0.00001837808,0.0008692641],"genre_scores_gemma":[0.9973569,0.001861503,0.000309118,0.000161853,0.0001330027,0.00004411041,0.00005212734,0.00002388074,0.00005751337],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.7029892,"threshold_uncertainty_score":0.8139458,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1875187441713972,"score_gpt":0.4893173829288177,"score_spread":0.3017986387574205,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}