{"id":"W4411018155","doi":"10.70962/jhi.20250014","title":"Two different forms of inherited human TCRα chain deficiency","year":2025,"lang":"en","type":"article","venue":"Journal of Human Immunity","topic":"Immunodeficiency and Autoimmune Disorders","field":"Immunology and Microbiology","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"SickKids Foundation; Hospital for Sick Children","funders":"National Center for Research Resources; National Center for Advancing Translational Sciences; Agence Nationale de la Recherche; Fondation Bettencourt Schueller; National Institutes of Health; Institut National Du Cancer; Institut National de la Santé et de la Recherche Médicale; SCOR Corporate Foundation for Science; National Institute of Allergy and Infectious Diseases; Rockefeller University; Institut des maladies génétiques Imagine; St. Giles Foundation","keywords":"T-cell receptor; Chain (unit); Genetics; Biology; T cell; Physics; Immune system","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007739656,0.0002485099,0.0006733385,0.0005305336,0.0007375916,0.00002256819,0.0008677552,0.0001809024,0.0003904152],"category_scores_gemma":[0.0001046706,0.000192737,0.0003750856,0.0003423734,0.0005126568,0.0001694745,0.000205878,0.0009808536,0.00001227968],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000749653,"about_ca_system_score_gemma":0.00007999402,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001983431,"about_ca_topic_score_gemma":0.00002089678,"domain_scores_codex":[0.9978198,0.0003644223,0.001204549,0.0001368143,0.0000898321,0.0003845134],"domain_scores_gemma":[0.9982872,0.0001109228,0.0008267182,0.0004838201,0.0002818212,0.000009490562],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001310134,0.001106116,0.002090204,0.00006675895,0.000204682,0.00000315234,0.001382483,0.00001172081,0.9739442,0.01770328,0.0001809088,0.003175463],"study_design_scores_gemma":[0.01266624,0.002528687,0.4052138,0.0009747347,0.0003876086,0.0001458267,0.01193776,0.000004696499,0.5436377,0.01679666,0.00499714,0.0007091342],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9766167,0.01583106,0.0001033799,0.00009904314,0.0005646578,0.000149876,0.000007055743,0.0000228689,0.006605342],"genre_scores_gemma":[0.9984407,0.0000871642,0.000007670276,0.0001105912,0.000004243822,0.000003329796,0.00002875123,0.00001304374,0.001304537],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4303065,"threshold_uncertainty_score":0.7859587,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01353389937701617,"score_gpt":0.2844418872569638,"score_spread":0.2709079878799476,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}