{"id":"W4411018155","doi":"10.70962/jhi.20250014","title":"Two different forms of inherited human TCRα chain deficiency","year":2025,"lang":"en","type":"article","venue":"Journal of Human Immunity","topic":"Immunodeficiency and Autoimmune Disorders","field":"Immunology and Microbiology","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"SickKids Foundation; Hospital for Sick Children","funders":"National Center for Research Resources; National Center for Advancing Translational Sciences; Agence Nationale de la Recherche; Fondation Bettencourt Schueller; National Institutes of Health; Institut National Du Cancer; Institut National de la Santé et de la Recherche Médicale; SCOR Corporate Foundation for Science; National Institute of Allergy and Infectious Diseases; Rockefeller University; Institut des maladies génétiques Imagine; St. Giles Foundation","keywords":"T-cell receptor; Chain (unit); Genetics; Biology; T cell; Physics; Immune system","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009298672,0.0007359291,0.0002476767,0.000432662,0.0001809087,0.0002008095,0.0002348148,0.0004515477,0.001446503],"category_scores_gemma":[0.000377234,0.0001121174,0.0002391076,0.0002945788,0.0004301168,0.0001595575,0.0004411163,0.0004604151,0.0002500976],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002049459,"about_ca_system_score_gemma":0.0002011648,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004512898,"about_ca_topic_score_gemma":0.0004127542,"domain_scores_codex":[0.9998146,0.00002620795,0.00003806894,0.00004695376,0.00003561757,0.00003867338],"domain_scores_gemma":[0.9998437,0.00002463594,0.0000636114,0.00001625787,0.00000945894,0.00004234387],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.001973194,0.0004062064,0.05476155,0.0004763044,0.0001271302,0.1245456,0.0007026978,0.0005610552,0.7653984,0.003628369,0.001415093,0.04600435],"study_design_scores_gemma":[0.0001875619,0.001862733,0.13784,0.00006494192,0.0001370558,0.7277009,0.0003002364,0.0006679251,0.1187887,0.0009058702,0.01148394,0.0000600944],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9915602,0.001724366,0.002405886,0.0001324108,0.00004782011,0.00007431131,0.0007020553,0.00007604613,0.00327699],"genre_scores_gemma":[0.995605,0.0009492669,0.001673101,0.0001267513,0.00001811479,0.00003368349,0.0004892248,0.00001131042,0.001093614],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001446503,"threshold_uncertainty_score":0.004839063,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01353389937701617,"score_gpt":0.2844418872569638,"score_spread":0.2709079878799476,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}