{"id":"W4411020943","doi":"10.1101/2025.06.02.657344","title":"E2F deregulation compromises ER homeostasis by attenuating IRE1 activity","year":2025,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Endoplasmic Reticulum Stress and Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"National Institutes of Health","keywords":"Deregulation; Homeostasis; E2F; Cell biology; Business; Chemistry; Economics; Market economy; Biology; Apoptosis; Biochemistry; Cell cycle","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001354278,0.0003048149,0.0002501815,0.0001809152,0.0001011648,0.0002978312,0.0002644405,0.000293275,0.001613165],"category_scores_gemma":[0.0001022089,0.00009209017,0.0001890304,0.000130042,0.0002174476,0.0001832669,0.000164957,0.0005315433,0.0003675629],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002316824,"about_ca_system_score_gemma":0.00009950432,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003389255,"about_ca_topic_score_gemma":0.0003449282,"domain_scores_codex":[0.9998763,0.00001443921,0.00001967502,0.00003681448,0.00002320355,0.00002950379],"domain_scores_gemma":[0.9999014,0.00002357256,0.00002800424,0.00001686745,0.000009788184,0.00002033574],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007739145,0.00002254401,0.0001669914,0.00002325171,0.000005394775,0.00004527634,0.000004138464,0.0000518507,0.9986787,0.00008420309,0.00004969627,0.0007904765],"study_design_scores_gemma":[0.000008598497,0.00005980909,0.001459548,0.000002022322,0.000006580478,0.000138269,0.00001119865,0.0004352387,0.9958212,0.0000233165,0.002032044,0.000002212927],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9931376,0.001999659,0.002750101,0.000165401,0.00005908341,0.00002252398,0.0006628358,0.0001186871,0.001084091],"genre_scores_gemma":[0.993961,0.0006610521,0.001807501,0.00008957714,0.00000986149,0.00002362001,0.0007118746,0.00003070455,0.002704953],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001613165,"threshold_uncertainty_score":0.005396605,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009573186867890356,"score_gpt":0.2330632078343317,"score_spread":0.2234900209664413,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}