{"id":"W4411024176","doi":"10.1016/j.cels.2025.101300","title":"A systems view of cellular heterogeneity: Unlocking the “wheel of fate”","year":2025,"lang":"en","type":"review","venue":"Cell Systems","topic":"Pluripotent Stem Cells Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":7,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of British Columbia","funders":"National Research Council Canada; Natural Sciences and Engineering Research Council of Canada; Canada Research Chairs; Canadian Institutes of Health Research; Sick Kids Foundation; Royan Institute; Michael Smith Health Research BC; Stem Cell Network; Paul G. Allen Frontiers Group","keywords":"Cell fate determination; Systems biology; Biology; Stem cell biology; Developmental biology; Induced pluripotent stem cell; Synthetic biology; Computational biology; Homogeneous; Stem cell; Juxtacrine signalling; Regenerative medicine; Cellular differentiation; Neuroscience; Computer science; Cell biology; Embryonic stem cell; Cell culture; Genetics; Transcription factor","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.001227067,0.0005447933,0.002187848,0.0001960699,0.00009004402,0.00005704085,0.0013711,0.0006756827,0.000003883847],"category_scores_gemma":[0.00006328757,0.0003684631,0.0008841148,0.0004496618,0.0001572898,0.000002675444,0.0005976144,0.0003147055,0.00002503664],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005988517,"about_ca_system_score_gemma":0.000581254,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000201625,"about_ca_topic_score_gemma":0.000004682782,"domain_scores_codex":[0.995495,0.001236705,0.001515058,0.0007078864,0.000557056,0.0004883525],"domain_scores_gemma":[0.9966191,0.0001594266,0.001114459,0.001721318,0.0002829076,0.0001028118],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"systematic_review","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00002746695,0.0002768703,0.00003482716,0.875311,0.001854243,0.00003674433,0.00004729911,0.0003914877,0.05433471,0.0001517824,0.004183089,0.06335045],"study_design_scores_gemma":[0.000176431,0.0001009348,1.888902e-7,0.02002225,0.0004651138,0.00002632836,0.00005655037,0.00005975609,0.01064877,4.153831e-7,0.9681396,0.0003036743],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0001927452,0.9922879,0.0006914814,0.000002472539,0.0009793164,0.002536315,0.000204567,0.00001105139,0.003094127],"genre_scores_gemma":[0.01145643,0.9825944,0.000006519482,0.000003429358,0.0002688222,0.0002947101,0.0002913309,0.00007255877,0.005011742],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9639565,"threshold_uncertainty_score":0.9998767,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03457646699281889,"score_gpt":0.3093342602309513,"score_spread":0.2747577932381324,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}