{"id":"W4411025725","doi":"10.1200/jco.2025.43.17_suppl.lba5","title":"Event-free survival (EFS) in MATTERHORN: A randomized, phase 3 study of durvalumab plus 5-fluorouracil, leucovorin, oxaliplatin and docetaxel chemotherapy (FLOT) in resectable gastric/gastroesophageal junction cancer (GC/GEJC).","year":2025,"lang":"en","type":"article","venue":"Journal of Clinical Oncology","topic":"Gastric Cancer Management and Outcomes","field":"Medicine","cited_by":15,"is_retracted":false,"has_abstract":true,"ca_institutions":"Centre Hospitalier de l’Université de Montréal","funders":"","keywords":"Docetaxel; Medicine; Oxaliplatin; Fluorouracil; Cancer; Chemotherapy; Internal medicine; Durvalumab; Gastroesophageal Junction; Oncology; Phases of clinical research; Adenocarcinoma; Colorectal cancer; Immunotherapy","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00179177,0.001363159,0.002014559,0.0003606375,0.0003792482,0.0008013933,0.0008172616,0.001350545,0.004981147],"category_scores_gemma":[0.001058333,0.0005114936,0.001563629,0.0003213808,0.0009585557,0.0009238229,0.0005382765,0.002589301,0.0006712049],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007019182,"about_ca_system_score_gemma":0.001242648,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006411619,"about_ca_topic_score_gemma":0.002458663,"domain_scores_codex":[0.999493,0.0002812747,0.0000245501,0.00007759643,0.00003555057,0.00008806405],"domain_scores_gemma":[0.9993373,0.0001194592,0.0001586405,0.0000492553,0.00003722264,0.0002982084],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9713689,0.01198704,0.001019714,0.0002333953,0.0004050884,0.00003273064,0.00004858361,0.0002738611,0.003522575,0.00005887156,0.0006249176,0.01042443],"study_design_scores_gemma":[0.8465339,0.1479418,0.003638258,0.00001789181,0.0003722516,0.00004282789,0.00002225083,0.0003819222,0.000482098,0.00009171578,0.0004643987,0.00001082377],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9943109,0.001086714,0.0003039783,0.0002755591,0.0001555993,0.002036805,0.0006385942,0.00005518383,0.001136748],"genre_scores_gemma":[0.9902474,0.0009495346,0.001089748,0.0008884755,0.0002282943,0.003265673,0.001251206,0.00001815607,0.00206147],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004981147,"threshold_uncertainty_score":0.01666367,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06781187243049028,"score_gpt":0.4583103592518422,"score_spread":0.3904984868213519,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}