{"id":"W4411028189","doi":"10.1200/jco.2025.43.17_suppl.lba4","title":"Camizestrant + CDK4/6 inhibitor (CDK4/6i) for the treatment of emergent <i>ESR1</i> mutations during first-line (1L) endocrine-based therapy (ET) and ahead of disease progression in patients (pts) with HR+/HER2– advanced breast cancer (ABC): Phase 3, double-blind ctDNA-guided SERENA-6 trial.","year":2025,"lang":"en","type":"article","venue":"Journal of Clinical Oncology","topic":"Advanced Breast Cancer Therapies","field":"Medicine","cited_by":18,"is_retracted":false,"has_abstract":true,"ca_institutions":"BC Cancer Agency","funders":"","keywords":"Medicine; Endocrine system; Disease; Oncology; First line treatment; Palbociclib; Internal medicine; Cancer; Hormone; Chemotherapy; Metastatic breast cancer; Breast cancer","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007654275,0.0007494386,0.001011553,0.0002842213,0.0002830909,0.0005958882,0.0004944694,0.0007454438,0.004354042],"category_scores_gemma":[0.0005481542,0.0003167094,0.000836859,0.000250659,0.0005057503,0.0006245298,0.0002858521,0.001923035,0.0006792286],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006505557,"about_ca_system_score_gemma":0.000844613,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006584586,"about_ca_topic_score_gemma":0.002801827,"domain_scores_codex":[0.9998279,0.00006965034,0.00001078398,0.00003339031,0.00001658424,0.00004175309],"domain_scores_gemma":[0.9996307,0.00005399076,0.00009739277,0.00002527209,0.00001785675,0.000174766],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.8694503,0.01675569,0.006754529,0.000805043,0.0009158861,0.0001419699,0.0001470279,0.00163138,0.01707207,0.0002443074,0.00286922,0.08321255],"study_design_scores_gemma":[0.7010365,0.2736783,0.01524328,0.00007628519,0.0006607057,0.0003765402,0.00006236788,0.001208181,0.003442269,0.0003263748,0.003857618,0.00003153157],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9897698,0.002847115,0.0004330567,0.0003891266,0.0001309552,0.002266034,0.001098707,0.0001231691,0.002942067],"genre_scores_gemma":[0.9918807,0.001529633,0.001084494,0.0005979943,0.0001125693,0.001456578,0.001320873,0.00001781658,0.001999296],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004354042,"threshold_uncertainty_score":0.01456571,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.09887842059387833,"score_gpt":0.4985457819358709,"score_spread":0.3996673613419925,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}