{"id":"W4411028356","doi":"10.1200/jco.2025.43.17_suppl.lba5006","title":"Phase 3 AMPLITUDE trial: Niraparib (NIRA) and abiraterone acetate plus prednisone (AAP) for metastatic castration-sensitive prostate cancer (mCSPC) patients (pts) with alterations in homologous recombination repair (HRR) genes.","year":2025,"lang":"en","type":"article","venue":"Journal of Clinical Oncology","topic":"Prostate Cancer Treatment and Research","field":"Medicine","cited_by":18,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"","keywords":"Abiraterone acetate; Medicine; Prostate cancer; Prednisone; Oncology; Internal medicine; Homologous recombination; CYP17A1; Cancer research; Gene; Cancer; Endocrinology; Androgen deprivation therapy; Genetics; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001333743,0.001495027,0.001731012,0.0003811186,0.0003898814,0.001164219,0.0008490077,0.001225966,0.01181953],"category_scores_gemma":[0.001167263,0.000482392,0.001731285,0.000438501,0.0007461247,0.0009027464,0.0004742517,0.003125104,0.001773599],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007161321,"about_ca_system_score_gemma":0.001569072,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009618862,"about_ca_topic_score_gemma":0.002507317,"domain_scores_codex":[0.9996289,0.0001962095,0.00001537507,0.00005801535,0.00004152252,0.0000599944],"domain_scores_gemma":[0.9994621,0.000100345,0.0001457727,0.00004696627,0.00003749906,0.0002073378],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9488895,0.009175697,0.0009443462,0.0008243736,0.0007502814,0.00006744443,0.0000675511,0.0009646326,0.00495089,0.0003279294,0.003535718,0.02950165],"study_design_scores_gemma":[0.942058,0.05300243,0.001788071,0.00004348674,0.0002768062,0.00009504076,0.00001642932,0.0005166757,0.0003098542,0.0003335791,0.001547799,0.00001177623],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9615682,0.007975865,0.001507692,0.001982025,0.0007937084,0.01061803,0.005225565,0.0005041981,0.009824705],"genre_scores_gemma":[0.9616539,0.004921073,0.003353951,0.003298086,0.0007568978,0.01167116,0.005532489,0.00009306642,0.008719476],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01181953,"threshold_uncertainty_score":0.03954029,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1194777830556377,"score_gpt":0.4936455053934625,"score_spread":0.3741677223378247,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}