{"id":"W4411035085","doi":"10.1101/2025.06.02.657148","title":"A histidine switch regulates pH-dependent filament formation by the caspase-9 CARD","year":2025,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Cellular transport and secretion","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of General Medical Sciences; National Institutes of Health; University of Toronto","keywords":"Histidine; Protein filament; Cell biology; Chemistry; Biophysics; Caspase; Biochemistry; Nanotechnology; Biology; Apoptosis; Materials science; Programmed cell death; Amino acid","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009853564,0.0001120883,0.00007882142,0.00005617307,0.00011907,0.0001555987,0.0001523662,0.0001793423,0.001190254],"category_scores_gemma":[0.0001406414,0.00009438428,0.00009740468,0.00004629587,0.0001910846,0.0001474482,0.0001379391,0.0002742776,0.0003156101],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002815389,"about_ca_system_score_gemma":0.00006586596,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003294224,"about_ca_topic_score_gemma":0.000239335,"domain_scores_codex":[0.9999471,0.00001093907,0.000003530672,0.00001298109,0.0000117059,0.00001380542],"domain_scores_gemma":[0.999872,0.00003413397,0.00004322153,0.00001000756,0.00001068542,0.00002983678],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000927096,0.00001170992,0.0002334768,0.000006947122,0.00000121722,0.00004561536,0.000006944075,0.00006797213,0.999143,0.00007020929,0.0000206415,0.0002995827],"study_design_scores_gemma":[0.00001948786,0.00005967871,0.006286699,0.000003030888,0.000002506147,0.0001274441,0.00001776691,0.003281874,0.9896708,0.00007532723,0.0004513595,0.000004143938],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9984308,0.00007737629,0.001017517,0.00002601101,0.000004613417,0.000003965947,0.00006669808,0.00001966463,0.0003534128],"genre_scores_gemma":[0.9987538,0.00003561077,0.0008514196,0.00001357629,0.000001643492,0.000002783846,0.00006206775,0.000007713322,0.0002714782],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001190254,"threshold_uncertainty_score":0.003981769,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008014823408192793,"score_gpt":0.1997389139916417,"score_spread":0.1917240905834489,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}