{"id":"W4411036191","doi":"10.1101/2025.06.03.657666","title":"Global proteomic analysis of <i>Cryptococcus neoformans</i> clinical strains reveals significant differences between latent and lethal infection","year":2025,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Fungal Infections and Studies","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Guelph","funders":"Canadian Institutes of Health Research; National Institutes of Health; Canada Research Chairs; University of Minnesota","keywords":"Cryptococcus neoformans; Biology; Microbiology; Cryptococcus; Cryptococcosis","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001684343,0.0002898843,0.0001885149,0.0003603339,0.0001401347,0.0003745647,0.0001144762,0.0002778585,0.0007220553],"category_scores_gemma":[0.0002312783,0.00008509539,0.0002206857,0.0002754991,0.0001908752,0.0001692947,0.0001922282,0.0003680426,0.0002449287],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002094235,"about_ca_system_score_gemma":0.000156455,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008685493,"about_ca_topic_score_gemma":0.0007114029,"domain_scores_codex":[0.9998724,0.00001364225,0.00001050298,0.00003208451,0.00003329808,0.00003800795],"domain_scores_gemma":[0.9998517,0.00002089325,0.00004647041,0.00001093596,0.00002933464,0.00004065455],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002818329,0.00003302386,0.007370135,0.00004950307,0.0000161401,0.00009379959,0.00002485134,0.0000407475,0.9897977,0.00003035455,0.000104384,0.00215741],"study_design_scores_gemma":[0.00002014208,0.0008651905,0.5266635,0.00003753059,0.00007803441,0.002331067,0.0003987406,0.002273296,0.4641123,0.0001979424,0.002997889,0.00002430403],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9961851,0.0005961551,0.001061686,0.00007578777,0.00001399642,0.0000276885,0.001386625,0.00003577551,0.0006170011],"genre_scores_gemma":[0.9950885,0.0004572705,0.001635611,0.0001381852,0.000009146464,0.00002804359,0.001881802,0.00001696904,0.0007445099],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008685493,"threshold_uncertainty_score":0.002415478,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0386354857087086,"score_gpt":0.3060942281646786,"score_spread":0.26745874245597,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}