{"id":"W4411036584","doi":"10.1038/s42255-025-01305-x","title":"State-dependent central synaptic regulation by GLP-1 is essential for energy homeostasis","year":2025,"lang":"en","type":"article","venue":"Nature Metabolism","topic":"Diet and metabolism studies","field":"Medicine","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"National Institute of Diabetes and Digestive and Kidney Diseases; National Institute of Mental Health; National Institute on Alcohol Abuse and Alcoholism; Servier; Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; National Institutes of Health; Robert Wood Johnson Foundation","keywords":"Energy homeostasis; Homeostasis; Glucose homeostasis; State (computer science); Neuroscience; Biology; Cell biology; Computer science; Endocrinology; Diabetes mellitus; Insulin resistance; Biochemistry; Receptor","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0001929452,0.000308356,0.0006917306,0.0002468578,0.000168818,0.00004849281,0.0001473775,0.0003687438,0.00008605317],"category_scores_gemma":[0.0001892997,0.0002569748,0.0002819199,0.000392296,0.00006815539,0.0001218327,0.00007761343,0.000364495,0.000006798381],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005530086,"about_ca_system_score_gemma":0.0001536783,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00007834375,"about_ca_topic_score_gemma":0.00002591494,"domain_scores_codex":[0.9980631,0.00004581946,0.0003791779,0.0004997013,0.0004412403,0.0005708879],"domain_scores_gemma":[0.9989753,0.00006827613,0.0001193951,0.0003667253,0.0003222343,0.0001480362],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00162899,0.0005715081,0.0007635945,0.0003946618,0.003062569,0.00001315964,0.0008506799,0.000007687651,0.04713226,0.05028741,0.7001229,0.1951646],"study_design_scores_gemma":[0.003607743,0.00003919454,0.03249019,0.00005955109,0.001596789,0.000002694787,0.0001064356,0.0001083373,0.07753262,0.004084226,0.8801022,0.0002700698],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"review","genre_gemma":"empirical","genre_scores_codex":[0.3087807,0.5834278,0.03203944,0.03456619,0.02335889,0.003153533,0.001670812,0.0007235968,0.012279],"genre_scores_gemma":[0.9714971,0.003863934,0.001091798,0.004079468,0.000731547,0.000111738,0.0002262442,0.00004342079,0.01835476],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.6627164,"threshold_uncertainty_score":0.9999883,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004585403103408267,"score_gpt":0.2637301640301136,"score_spread":0.2591447609267054,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}