{"id":"W4411045545","doi":"10.1111/all.16605","title":"Gene–Environment Interaction Affects Risk of Atopic Eczema: Population and In Vitro Studies","year":2025,"lang":"en","type":"article","venue":"Allergy","topic":"Dermatology and Skin Diseases","field":"Medicine","cited_by":9,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Leibniz-Gemeinschaft; Manchester Biomedical Research Centre; European Social Fund; École des Hautes Études en Santé Publique; Agencia Estatal de Investigación; Università degli Studi di Torino; Rigshospitalet; Newcastle University; Universitair Medisch Centrum Groningen; European Commission; Universitat Jaume I; Lung Foundation Netherlands; Newcastle upon Tyne Hospitals NHS Foundation Trust; University College Cork; Medizinischen Hochschule Hannover; Universitat de València; Euskal Herriko Unibertsitatea; Karolinska Institutet; ZonMw; Asthma and Lung UK; Kuwait University; Rijksuniversiteit Groningen; Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana; School of Medicine, Stanford University; Institut National de la Santé et de la Recherche Médicale; Fakultet Medicinskih Nauka, Univerziteta U Kragujevcu; St. Olavs Hospital Universitetssykehuset i Trondheim; Trinity College Dublin; NIHR Bristol Biomedical Research Centre; Ministerio de Ciencia e Innovación; Innovative Medicines Initiative; European Research Council; King's College London; University of Bristol; Wellcome Trust; Medical Research Council; Department of Health and Social Care; Bundesministerium für Bildung und Forschung; National Institute for Health and Care Research; Directorate for Biological Sciences; Imperial College London; Innovative Medicines Canada; Ministerio de Ciencia, Innovación y Universidades; European Federation of Pharmaceutical Industries and Associations; Nederlandse Organisatie voor Wetenschappelijk Onderzoek; Hunter Medical Research Institute; European Science Foundation; NIHR Newcastle Biomedical Research Centre; Norges Teknisk-Naturvitenskapelige Universitet","keywords":"Genotype; Gene–environment interaction; Sibling; Genetics; Biology; Allele; Genome-wide association study; Gene; Immunology; Psychology; Single-nucleotide polymorphism; Developmental psychology","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00003516419,0.00004555366,0.0001467441,0.00006988269,0.00001793444,0.000001004015,0.00001196192,0.00003275669,0.000008460251],"category_scores_gemma":[0.000057086,0.00003942681,0.00002119686,0.0000349623,0.00002884013,0.0000273316,0.0000235039,0.00004325456,0.000001473573],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002461655,"about_ca_system_score_gemma":0.000005542086,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000040334,"about_ca_topic_score_gemma":0.00003306645,"domain_scores_codex":[0.9996824,0.0000411182,0.00009801569,0.00008889687,0.00003797237,0.00005163638],"domain_scores_gemma":[0.9997956,0.00006818839,0.0000388969,0.0000772214,0.000005912331,0.00001424763],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0006395501,0.0002541196,0.9746299,0.0002368365,0.0005937974,0.0000454024,0.0003201056,0.0001367123,0.003698398,0.0001499093,0.001510745,0.01778453],"study_design_scores_gemma":[0.0006904831,0.00001779245,0.9871914,0.00006312596,0.00005088218,0.00000604589,0.0001258231,0.0001553633,0.01045251,0.0005593972,0.0006585108,0.00002871245],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9946712,0.004481099,0.00001446094,0.0003121574,0.00009232883,0.0000877838,0.000001170167,0.000006702262,0.0003331215],"genre_scores_gemma":[0.9977953,0.001834436,0.00009755237,0.0001024623,0.000009435858,0.00001035409,0.00001340408,0.000002117185,0.0001349065],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01775582,"threshold_uncertainty_score":0.1607779,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01103268795449955,"score_gpt":0.2844585384141753,"score_spread":0.2734258504596757,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}