{"id":"W4411045545","doi":"10.1111/all.16605","title":"Gene–Environment Interaction Affects Risk of Atopic Eczema: Population and In Vitro Studies","year":2025,"lang":"en","type":"article","venue":"Allergy","topic":"Dermatology and Skin Diseases","field":"Medicine","cited_by":9,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Leibniz-Gemeinschaft; Manchester Biomedical Research Centre; European Social Fund; École des Hautes Études en Santé Publique; Agencia Estatal de Investigación; Università degli Studi di Torino; Rigshospitalet; Newcastle University; Universitair Medisch Centrum Groningen; European Commission; Universitat Jaume I; Lung Foundation Netherlands; Newcastle upon Tyne Hospitals NHS Foundation Trust; University College Cork; Medizinischen Hochschule Hannover; Universitat de València; Euskal Herriko Unibertsitatea; Karolinska Institutet; ZonMw; Asthma and Lung UK; Kuwait University; Rijksuniversiteit Groningen; Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana; School of Medicine, Stanford University; Institut National de la Santé et de la Recherche Médicale; Fakultet Medicinskih Nauka, Univerziteta U Kragujevcu; St. Olavs Hospital Universitetssykehuset i Trondheim; Trinity College Dublin; NIHR Bristol Biomedical Research Centre; Ministerio de Ciencia e Innovación; Innovative Medicines Initiative; European Research Council; King's College London; University of Bristol; Wellcome Trust; Medical Research Council; Department of Health and Social Care; Bundesministerium für Bildung und Forschung; National Institute for Health and Care Research; Directorate for Biological Sciences; Imperial College London; Innovative Medicines Canada; Ministerio de Ciencia, Innovación y Universidades; European Federation of Pharmaceutical Industries and Associations; Nederlandse Organisatie voor Wetenschappelijk Onderzoek; Hunter Medical Research Institute; European Science Foundation; NIHR Newcastle Biomedical Research Centre; Norges Teknisk-Naturvitenskapelige Universitet","keywords":"Genotype; Gene–environment interaction; Sibling; Genetics; Biology; Allele; Genome-wide association study; Gene; Immunology; Psychology; Single-nucleotide polymorphism; Developmental psychology","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.005220062,0.0007508107,0.0008875634,0.0008064808,0.0003765609,0.001153879,0.0006835714,0.0008105125,0.003472075],"category_scores_gemma":[0.005299891,0.0004672922,0.001652868,0.001150621,0.000670866,0.000363213,0.0006593981,0.0008740207,0.0005785468],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003504042,"about_ca_system_score_gemma":0.0003286313,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002039641,"about_ca_topic_score_gemma":0.001683859,"domain_scores_codex":[0.9941812,0.004027351,0.0003480765,0.0007876595,0.0004566064,0.0001990423],"domain_scores_gemma":[0.9924511,0.004444373,0.001065118,0.001262914,0.0005628905,0.000213498],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.008141256,0.00255443,0.778393,0.0008915467,0.009647042,0.002216819,0.001185538,0.003185571,0.1704711,0.0009189611,0.001498688,0.02089602],"study_design_scores_gemma":[0.0009175682,0.01039718,0.9047862,0.0001250059,0.008495124,0.005504706,0.0008661221,0.007356644,0.05416654,0.00131433,0.005897428,0.0001731806],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9910979,0.003411157,0.003299165,0.0001533857,0.00005190215,0.0000715655,0.001011009,0.00002446058,0.0008794912],"genre_scores_gemma":[0.9964094,0.0008273954,0.001321361,0.0001437921,0.00005243671,0.00006484117,0.0007667098,0.00001176692,0.0004024089],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005220062,"threshold_uncertainty_score":0.02760661,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01103268795449955,"score_gpt":0.2844585384141753,"score_spread":0.2734258504596757,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}