{"id":"W4411055081","doi":"10.1007/s11523-025-01153-5","title":"Circulating Tumor DNA in Advanced EGFRex20+ NSCLC: Concordance with Tissue Biopsy, Monitoring of Response, and Resistance to High-Dose Osimertinib","year":2025,"lang":"en","type":"article","venue":"Targeted Oncology","topic":"Cancer Genomics and Diagnostics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Newfoundland and Labrador; AstraZeneca","keywords":"Medicine; Osimertinib; Concordance; Acquired resistance; Biopsy; Oncology; Circulating tumor DNA; Pathology; Internal medicine; Cancer; Adenocarcinoma","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003661901,0.000154992,0.0002009616,0.0003808674,0.0001310843,0.0002807677,0.0001574574,0.0002805839,0.0009661994],"category_scores_gemma":[0.001245925,0.0001273866,0.00008736201,0.000244346,0.000155112,0.0001816968,0.000146737,0.0002178722,0.0001638544],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001732819,"about_ca_system_score_gemma":0.00009301315,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003712238,"about_ca_topic_score_gemma":0.000577579,"domain_scores_codex":[0.9997721,0.00004865979,0.00003412138,0.00005926832,0.00006234352,0.00002356097],"domain_scores_gemma":[0.9992048,0.0002128476,0.000335498,0.00003624924,0.0001075271,0.0001029805],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0007830525,0.00005488242,0.9755369,0.00002467724,0.00003235063,0.0005430071,0.0000871141,0.0001333243,0.01673812,0.00001276208,0.00004817022,0.00600567],"study_design_scores_gemma":[0.00003870397,0.001169891,0.9840349,0.000008094429,0.00005022527,0.005811771,0.0001147415,0.0007786409,0.007589574,0.00002689816,0.0003713014,0.000005296381],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.999481,0.0001836504,0.0001126909,0.000006977703,0.0000017845,0.000004466927,0.00003984876,0.000003722808,0.000165907],"genre_scores_gemma":[0.9996954,0.00004398124,0.0001009474,0.000007776815,0.000002675035,0.000003913681,0.00007381885,7.768137e-7,0.00007080942],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009661994,"threshold_uncertainty_score":0.003232241,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006775695507202522,"score_gpt":0.2802244547159031,"score_spread":0.2734487592087006,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}