{"id":"W4411055081","doi":"10.1007/s11523-025-01153-5","title":"Circulating Tumor DNA in Advanced EGFRex20+ NSCLC: Concordance with Tissue Biopsy, Monitoring of Response, and Resistance to High-Dose Osimertinib","year":2025,"lang":"en","type":"article","venue":"Targeted Oncology","topic":"Cancer Genomics and Diagnostics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Newfoundland and Labrador; AstraZeneca","keywords":"Medicine; Osimertinib; Concordance; Acquired resistance; Biopsy; Oncology; Circulating tumor DNA; Pathology; Internal medicine; Cancer; Adenocarcinoma","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002553032,0.0001649472,0.0003270762,0.0001199513,0.00005251673,0.000009102005,0.0001549413,0.0001169444,0.000003937951],"category_scores_gemma":[0.0005027063,0.0001723131,0.00002189724,0.0003063567,0.0001152782,0.000004304229,0.0001262525,0.000109783,0.000001061144],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00009245567,"about_ca_system_score_gemma":0.0003915494,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00008877285,"about_ca_topic_score_gemma":0.0003981485,"domain_scores_codex":[0.9987602,0.00009910459,0.0003483954,0.0004304558,0.00007422941,0.0002876447],"domain_scores_gemma":[0.9991544,0.0001914418,0.0001480262,0.0003105534,0.0001166523,0.00007892838],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.004398358,0.00004802141,0.0201065,0.00004261107,0.00002802525,0.00005790396,0.0001237525,0.0004026652,0.9695062,0.0002494724,0.0001226579,0.004913826],"study_design_scores_gemma":[0.003227339,0.001239384,0.2166205,0.0002362228,0.00002619632,0.00001850674,0.0003230688,0.00001449388,0.7550409,0.0003050796,0.02264674,0.0003015773],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9951422,0.002411462,0.0006718727,0.0005493937,0.0002566234,0.0003555561,0.00003389982,0.00001008142,0.0005688774],"genre_scores_gemma":[0.9824583,0.00009439106,0.01678023,0.000232525,0.00008200469,0.0000741878,0.00001425664,0.00001967594,0.000244434],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2144653,"threshold_uncertainty_score":0.7026725,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006775695507202522,"score_gpt":0.2802244547159031,"score_spread":0.2734487592087006,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}