{"id":"W4411056554","doi":"10.1101/2025.06.02.657443","title":"Increased circulating TREM2 <sup>+</sup> microglial extracellular vesicles in aged APP/PS1 Alzheimer’s disease rats","year":2025,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Neuroinflammation and Neurodegeneration Mechanisms","field":"Neuroscience","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University","funders":"Natural Sciences and Engineering Research Council of Canada; Alzheimer Society; Alzheimer's Society","keywords":"TREM2; Microglia; Extracellular vesicles; Extracellular; Alzheimer's disease; Vesicle; Disease; Chemistry; Amyloid (mycology); Medicine; Neuroscience; Cell biology; Pathology; Immunology; Biochemistry; Biology; Inflammation","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001785697,0.0004274584,0.000403753,0.0006166063,0.0001976396,0.0004091723,0.0001246089,0.0003823889,0.001949006],"category_scores_gemma":[0.0001101304,0.000147272,0.0002379708,0.0001694688,0.0002858262,0.0003504087,0.0002314391,0.0007526557,0.0004274154],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002375044,"about_ca_system_score_gemma":0.0001673689,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006362431,"about_ca_topic_score_gemma":0.0006070302,"domain_scores_codex":[0.9998412,0.00001093494,0.00001298849,0.00005643061,0.00002842894,0.00004991866],"domain_scores_gemma":[0.9998385,0.00001016992,0.00005997848,0.00001248183,0.0000237922,0.00005502224],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001115892,0.00006616315,0.001122885,0.00005733713,0.00001475334,0.0001308895,0.00005739003,0.00003705428,0.9950536,0.00007251045,0.00008883251,0.002182861],"study_design_scores_gemma":[0.00005870281,0.001345444,0.05246962,0.00002072144,0.00007073797,0.0009150308,0.000231432,0.000762961,0.9421838,0.0002222979,0.001697954,0.00002130581],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9959207,0.0008617712,0.001429376,0.00008157385,0.0000403448,0.00001381911,0.0009631037,0.0000796115,0.0006096486],"genre_scores_gemma":[0.9918411,0.0006191747,0.00216343,0.0000784111,0.00003228895,0.00005794567,0.0009083335,0.0000382693,0.004261071],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001949006,"threshold_uncertainty_score":0.006520092,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0310158687872475,"score_gpt":0.2403397001599074,"score_spread":0.2093238313726599,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}