{"id":"W4411058935","doi":"10.1016/j.molcel.2025.05.012","title":"Off-pore Nup98 condensates mobilize heterochromatic breaks and exclude Rad51","year":2025,"lang":"en","type":"article","venue":"Molecular Cell","topic":"RNA modifications and cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":5,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Calgary","funders":"National Institute of General Medical Sciences; Directorate for Mathematical and Physical Sciences; Directorate for Biological Sciences; National Institute of Arthritis and Musculoskeletal and Skin Diseases; Grantová Agentura České Republiky; National Cancer Institute; National Science Foundation; National Institutes of Health; National Institute of Environmental Health Sciences; American Cancer Society","keywords":"Biology; Heterochromatin; RAD51; Cell biology; Nuclear pore; Computational biology; Genetics; DNA; DNA damage; Chromatin; Cytoplasm","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007452141,0.0001551853,0.0001399218,0.00004515595,0.00007540781,0.00004226761,0.0001530775,0.0001267499,0.00002751589],"category_scores_gemma":[0.00001711575,0.0001518513,0.00007452376,0.00008753305,0.00009591789,0.000002673211,0.00009987048,0.00006734673,0.000009088316],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001237475,"about_ca_system_score_gemma":0.00005630928,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000134522,"about_ca_topic_score_gemma":0.000006710731,"domain_scores_codex":[0.9991418,0.00004496264,0.0001780915,0.0003612669,0.00008300848,0.0001909131],"domain_scores_gemma":[0.9993778,0.000007439279,0.00005103229,0.0004507262,0.00005183532,0.00006118279],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001501144,0.00004843853,0.0002791299,0.00006045394,0.00003823927,0.000009092267,0.00002422062,0.00005960287,0.994213,0.000151702,0.001645193,0.003455949],"study_design_scores_gemma":[0.0007234026,0.00008711199,0.0009701472,0.00002559706,0.00004662154,0.00001200972,0.00007991856,0.0003394331,0.9434369,0.0004156808,0.05364523,0.0002179371],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9764211,0.01066904,0.003541706,0.0002140684,0.00008385797,0.0002146403,0.00001039163,0.0000170138,0.008828157],"genre_scores_gemma":[0.9944295,0.0003518403,0.0005921068,0.000741182,0.00002497343,0.00005287298,0.00008387057,0.00001882913,0.003704868],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.05200004,"threshold_uncertainty_score":0.6192317,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.003585477934198656,"score_gpt":0.2308559897424392,"score_spread":0.2272705118082405,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}