{"id":"W4411059978","doi":"10.1039/d5md00171d","title":"Design, synthesis and biological evaluation of <i>N</i>-pyridinyl ureidobenzenesulfonates and their hydrochloride salts as novel water-soluble dihydroorotate dehydrogenase inhibitors inducing differentiation of acute myeloid leukemia cells","year":2025,"lang":"en","type":"article","venue":"RSC Medicinal Chemistry","topic":"Biochemical and Molecular Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval; Institut universitaire de cardiologie et de pneumologie de Québec; Hôpital Saint-François d'Assise","funders":"Fonds de Recherche du Québec - Santé; Natural Sciences and Engineering Research Council of Canada; Canada Foundation for Innovation; Université Laval","keywords":"Dihydroorotate dehydrogenase; Myeloid leukemia; Chemistry; Hydrochloride; Leukemia; Dehydrogenase; Pharmacology; Biochemistry; Combinatorial chemistry; Enzyme; Cancer research; Biology; Immunology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000167127,0.0002941761,0.0002209813,0.00009424721,0.0001150475,0.0002650539,0.0002779361,0.000252824,0.0008030326],"category_scores_gemma":[0.0001073869,0.0001112836,0.000153694,0.0001197659,0.0001376475,0.0002220094,0.00015867,0.0002433161,0.0004103017],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000228969,"about_ca_system_score_gemma":0.0003021447,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004222039,"about_ca_topic_score_gemma":0.0009426739,"domain_scores_codex":[0.9999099,0.00001940022,0.00001153636,0.0000185042,0.0000247512,0.0000158066],"domain_scores_gemma":[0.9999373,0.000003738393,0.00002313176,0.000006782318,0.00001289472,0.00001618695],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001505072,0.00007040348,0.0001040333,0.0001332782,0.000007967195,0.00005288811,0.00001609671,0.0004894088,0.9900969,0.0003844972,0.0001150732,0.008378864],"study_design_scores_gemma":[0.00005170629,0.001115475,0.0003915276,0.00000520508,0.00001263468,0.0001100683,0.000008081677,0.0007341675,0.9918804,0.0000298473,0.005653736,0.000007165626],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9693835,0.003655644,0.0192943,0.0001534995,0.0000721307,0.0005967945,0.000632461,0.0002248559,0.005986787],"genre_scores_gemma":[0.979288,0.002266901,0.0141291,0.00006145052,0.00001728983,0.0001775817,0.0005111814,0.0000268458,0.003521592],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008030326,"threshold_uncertainty_score":0.002686381,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0183844373561036,"score_gpt":0.2607571553735528,"score_spread":0.2423727180174492,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}