{"id":"W4411059978","doi":"10.1039/d5md00171d","title":"Design, synthesis and biological evaluation of <i>N</i>-pyridinyl ureidobenzenesulfonates and their hydrochloride salts as novel water-soluble dihydroorotate dehydrogenase inhibitors inducing differentiation of acute myeloid leukemia cells","year":2025,"lang":"en","type":"article","venue":"RSC Medicinal Chemistry","topic":"Biochemical and Molecular Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval; Institut universitaire de cardiologie et de pneumologie de Québec; Hôpital Saint-François d'Assise","funders":"Fonds de Recherche du Québec - Santé; Natural Sciences and Engineering Research Council of Canada; Canada Foundation for Innovation; Université Laval","keywords":"Dihydroorotate dehydrogenase; Myeloid leukemia; Chemistry; Hydrochloride; Leukemia; Dehydrogenase; Pharmacology; Biochemistry; Combinatorial chemistry; Enzyme; Cancer research; Biology; Immunology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008107365,0.0002491591,0.0003406146,0.00005170402,0.00007403716,0.00001345465,0.0001736587,0.0003290161,0.00001823577],"category_scores_gemma":[0.000278924,0.0001748333,0.00007921607,0.0001144388,0.000279316,0.000007298026,0.0002548418,0.0001747824,4.33706e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000468806,"about_ca_system_score_gemma":0.0002070025,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00006589838,"about_ca_topic_score_gemma":0.000001424012,"domain_scores_codex":[0.9984065,0.00008763059,0.0003987912,0.0004974256,0.0003195611,0.0002900948],"domain_scores_gemma":[0.999166,0.0000846417,0.0001358337,0.0002660203,0.0002149838,0.0001325805],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000308265,0.00006981575,0.0001635274,0.0002475607,0.0002169239,0.000001565487,0.00006764621,0.00004491939,0.9968519,0.000003491456,0.00004206533,0.001982369],"study_design_scores_gemma":[0.0009844711,0.0001309589,0.0001072282,0.0001957936,0.0001686214,0.00002160913,0.00008929168,0.001634552,0.9962237,0.0002211975,0.00005166114,0.00017093],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9959377,0.001682429,0.001721646,0.0001012593,0.0000536013,0.0002874091,0.00002141551,0.000008957153,0.0001856067],"genre_scores_gemma":[0.9987584,0.0007448109,0.0001294391,0.00004587151,0.00006744169,0.00005403689,0.0001307521,0.0000155037,0.0000536836],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002820784,"threshold_uncertainty_score":0.7129497,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0183844373561036,"score_gpt":0.2607571553735528,"score_spread":0.2423727180174492,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}