{"id":"W4411063878","doi":"10.1002/advs.202500181","title":"An Engineered Soluble Single‐Chain TCR Engager for KRAS‐G12V Specific Tumor Immunotherapy","year":2025,"lang":"en","type":"article","venue":"Advanced Science","topic":"CAR-T cell therapy research","field":"Medicine","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Chinese Academy of Sciences; Basic and Applied Basic Research Foundation of Guangdong Province; National Key Research and Development Program of China; Peking Union Medical College; Institute of Genetics; Institute of Microbiology, Chinese Academy of Sciences; National Natural Science Foundation of China","keywords":"T-cell receptor; KRAS; Context (archaeology); T cell; Cancer research; Immunotherapy; Avidity; Antigen; Computational biology; Mutation; Biology; Molecular biology; Chemistry; Immunology; Genetics; Immune system; Gene","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00006814651,0.0002554905,0.0001547734,0.00009162837,0.00006059694,0.0002337453,0.0001673941,0.0003288945,0.0006281677],"category_scores_gemma":[0.00008160527,0.00009691705,0.0001489711,0.00009095943,0.00008335054,0.0001165587,0.0001552838,0.000430749,0.0003527977],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001711745,"about_ca_system_score_gemma":0.0001106973,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001532707,"about_ca_topic_score_gemma":0.0003250777,"domain_scores_codex":[0.9998963,0.00001311353,0.000007627769,0.00001848703,0.00003926774,0.00002527668],"domain_scores_gemma":[0.9999628,0.000002954563,0.00001649036,0.000003451613,0.000005155656,0.000009200774],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003598884,0.00003043084,0.0000759379,0.0000272721,0.000003898391,0.00005709909,0.00000735225,0.0004672771,0.9969254,0.0001548056,0.00008346989,0.002130993],"study_design_scores_gemma":[0.00002707945,0.0008755007,0.0006316802,0.000005596443,0.00001933518,0.0005296888,0.00001424638,0.004410798,0.9879988,0.00005621544,0.00542127,0.000009677647],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9816216,0.00131924,0.01387415,0.0001328808,0.00004720033,0.00006748966,0.0001866558,0.0002039059,0.002546899],"genre_scores_gemma":[0.9909583,0.0004929636,0.006540801,0.00006343801,0.0000100851,0.00003396567,0.0001824748,0.00001466352,0.001703169],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0006281677,"threshold_uncertainty_score":0.002101421,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02917516203647631,"score_gpt":0.3437539107347228,"score_spread":0.3145787486982465,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}