{"id":"W4411066308","doi":"10.3390/pharmaceutics17060741","title":"Linking TLR-7 Signaling to Downregulation of Placental P-Glycoprotein: Implications for Fetal Drug Exposure","year":2025,"lang":"en","type":"article","venue":"Pharmaceutics","topic":"Pregnancy and Medication Impact","field":"Medicine","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"Canadian Institutes of Health Research","keywords":"Downregulation and upregulation; Placenta; Immune system; Inflammation; Biology; Receptor; Fetus; Immunology; Internal medicine; Medicine; Pregnancy","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003556396,0.0003389486,0.0002226931,0.0002089375,0.0001501953,0.0004242039,0.0002264272,0.0004670611,0.002541991],"category_scores_gemma":[0.0004189644,0.000108324,0.0003577186,0.0001366281,0.0004589335,0.0003013377,0.0002724857,0.0007389364,0.0003046952],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005502119,"about_ca_system_score_gemma":0.0003414013,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003923493,"about_ca_topic_score_gemma":0.0002702972,"domain_scores_codex":[0.9998179,0.00005868182,0.00001442598,0.00003204631,0.00004265783,0.00003430508],"domain_scores_gemma":[0.99981,0.00004918363,0.00008144131,0.00001609181,0.00002324977,0.00002004185],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0008470672,0.0001136711,0.005213784,0.0005750026,0.00005889885,0.00190428,0.00007639106,0.0003770952,0.9561961,0.001338993,0.0006201623,0.0326785],"study_design_scores_gemma":[0.0000587998,0.001578598,0.02817405,0.0001508113,0.0001110097,0.007410254,0.000272156,0.002185116,0.9432851,0.001390308,0.01536389,0.00001986897],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9002092,0.05924288,0.0245931,0.007228618,0.0003186806,0.0001602676,0.000985558,0.0003338188,0.006927772],"genre_scores_gemma":[0.9773818,0.01672609,0.003407724,0.0006398615,0.00006834757,0.00008137037,0.0002233231,0.00001718269,0.001454274],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002541991,"threshold_uncertainty_score":0.008503795,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05063070667416511,"score_gpt":0.4006649027429408,"score_spread":0.3500341960687757,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}