{"id":"W4411077462","doi":"10.1038/s41419-025-07755-1","title":"Muscle stem cells in Duchenne muscular dystrophy exhibit molecular impairments and altered cell fate trajectories impacting regenerative capacity","year":2025,"lang":"en","type":"article","venue":"Cell Death and Disease","topic":"Muscle Physiology and Disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":17,"is_retracted":false,"has_abstract":true,"ca_institutions":"Montreal Neurological Institute and Hospital; McGill University","funders":"Defeat Duchenne Canada; Fonds de Recherche du Québec - Santé; Canadian Institutes of Health Research; Government of Canada; Muscular Dystrophy Canada; Stem Cell Network; McGill University","keywords":"Duchenne muscular dystrophy; Biology; Stem cell; Progenitor cell; Dystrophin; Cell biology; Myogenesis; mdx mouse; Regeneration (biology); Satellite; Cellular differentiation; Muscular dystrophy; Cell fate determination; Myocyte; Genetics; Gene; Transcription factor","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001543052,0.0002625002,0.0003657608,0.0004194999,0.0002561341,0.0003123849,0.00009653953,0.0002944721,0.001032984],"category_scores_gemma":[0.0001544595,0.0001634862,0.0002188299,0.0002740496,0.0002561278,0.0001610825,0.0002366438,0.0003598466,0.000372852],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000238187,"about_ca_system_score_gemma":0.0001986242,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001013568,"about_ca_topic_score_gemma":0.002455543,"domain_scores_codex":[0.9998206,0.00001421638,0.00002272139,0.00005362218,0.00006530317,0.00002346401],"domain_scores_gemma":[0.9998758,0.00001715797,0.00004509251,0.00001292378,0.00001694304,0.00003214249],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008688642,0.000014598,0.003786047,0.00008840614,0.00001117077,0.0002147797,0.0001278275,0.0001238363,0.9920614,0.0000621224,0.0000588286,0.003364125],"study_design_scores_gemma":[0.00002032762,0.0005793206,0.3603973,0.00008361503,0.00008468929,0.00281152,0.0007571158,0.002521898,0.624486,0.0004140437,0.007819378,0.00002465142],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9949408,0.001684019,0.001703972,0.00005468299,0.00001531663,0.00001412371,0.0008108895,0.0001162987,0.0006600902],"genre_scores_gemma":[0.9900209,0.001621883,0.003057363,0.0001118911,0.00000805558,0.00004956601,0.002059461,0.00003940994,0.003031536],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001032984,"threshold_uncertainty_score":0.003455639,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007203958155822287,"score_gpt":0.2180485184422994,"score_spread":0.2108445602864771,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}