{"id":"W4411085041","doi":"10.1097/qad.0000000000004251","title":"Virological success despite archived INSTI drug resistance mutations on INSTI-based antiretroviral regimens","year":2025,"lang":"en","type":"article","venue":"AIDS","topic":"HIV/AIDS drug development and treatment","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hotel Dieu Hospital","funders":"","keywords":"Medicine; Antiretroviral therapy; Integrase; Regimen; Human immunodeficiency virus (HIV); Drug resistance; Viral load; Drug; Prospective cohort study; Mutation; Internal medicine; Virology; Oncology; Pharmacology; Biology; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001555897,0.0002093298,0.0003155766,0.0003045736,0.0002254135,0.00002639659,0.0001211404,0.00006978816,0.00006006146],"category_scores_gemma":[0.0001539377,0.0001642051,0.0001079601,0.0003849651,0.000169015,0.00005693781,0.00003911315,0.0002215296,0.0001090461],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001302072,"about_ca_system_score_gemma":0.0002612506,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001389109,"about_ca_topic_score_gemma":0.00004924623,"domain_scores_codex":[0.9986882,0.00008625053,0.0002750643,0.0003783052,0.0002503531,0.0003218178],"domain_scores_gemma":[0.999209,0.0002365104,0.00005958597,0.0003300244,0.00005328497,0.0001116139],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.002221818,0.001658476,0.9330887,0.0001951937,0.0004626309,0.0008189496,0.0009871855,0.00008296812,0.002655316,0.02724539,0.0168399,0.01374348],"study_design_scores_gemma":[0.01647224,0.001244106,0.8385126,0.0013782,0.0007271988,0.000008411602,0.0002347906,0.000646483,0.03550724,0.003598097,0.1008796,0.0007909944],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9517962,0.000119969,0.0009815091,0.007961485,0.0001522972,0.0004223202,0.00001443521,0.000155229,0.0383965],"genre_scores_gemma":[0.9309667,0.00001441364,0.006958088,0.001529881,0.00003346534,0.00007113193,0.000158088,0.00001355595,0.06025472],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.09457608,"threshold_uncertainty_score":0.669609,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01166833208605382,"score_gpt":0.2798165266162131,"score_spread":0.2681481945301593,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}