{"id":"W4411085041","doi":"10.1097/qad.0000000000004251","title":"Virological success despite archived INSTI drug resistance mutations on INSTI-based antiretroviral regimens","year":2025,"lang":"en","type":"article","venue":"AIDS","topic":"HIV/AIDS drug development and treatment","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hotel Dieu Hospital","funders":"","keywords":"Medicine; Antiretroviral therapy; Integrase; Regimen; Human immunodeficiency virus (HIV); Drug resistance; Viral load; Drug; Prospective cohort study; Mutation; Internal medicine; Virology; Oncology; Pharmacology; Biology; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001238136,0.0001948579,0.0003481345,0.0005001778,0.0002820177,0.000742493,0.0003607625,0.000284094,0.0006263611],"category_scores_gemma":[0.004763272,0.0001129616,0.0001626122,0.0004435809,0.0004810113,0.0004236361,0.0002237773,0.0003190694,0.000163523],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003734421,"about_ca_system_score_gemma":0.0002726397,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001268045,"about_ca_topic_score_gemma":0.001294719,"domain_scores_codex":[0.9992765,0.0002200078,0.00007076879,0.000126382,0.0001883001,0.0001180732],"domain_scores_gemma":[0.9966195,0.001192808,0.001311507,0.000231667,0.0003545093,0.000290029],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0003962518,0.00002888791,0.992026,0.0000216053,0.00003558408,0.0004514966,0.000136767,0.0001031861,0.0005640153,0.00002576482,0.00005193946,0.006158401],"study_design_scores_gemma":[0.00001763182,0.001095746,0.9946806,0.00002789234,0.00004404159,0.00254118,0.0002401732,0.0003202119,0.0006078985,0.00004192146,0.0003772604,0.000005448868],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9989929,0.0004300445,0.00006148238,0.00001466043,0.000002406788,0.000006737958,0.00008829373,0.000003369601,0.0004000869],"genre_scores_gemma":[0.9998023,0.00005749446,0.00001860495,0.00001058916,0.00000655449,0.000001584631,0.00006692654,9.463877e-7,0.00003500062],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001268045,"threshold_uncertainty_score":0.006547987,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01166833208605382,"score_gpt":0.2798165266162131,"score_spread":0.2681481945301593,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}