{"id":"W4411085580","doi":"10.1126/sciimmunol.ads1328","title":"An <i>Il12</i> mRNA-LNP adjuvant enhances mRNA vaccine–induced CD8 T cell responses","year":2025,"lang":"en","type":"article","venue":"Science Immunology","topic":"Immune Cell Function and Interaction","field":"Immunology and Microbiology","cited_by":41,"is_retracted":false,"has_abstract":true,"ca_institutions":"Acuitas Therapeutics (Canada)","funders":"National Institute of Allergy and Infectious Diseases; National Cancer Institute","keywords":"Cytotoxic T cell; CD8; T cell; Adjuvant; Effector; Immunology; Biology; ELISPOT; Interleukin 12; Antigen; Immune system","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":["insufficient_payload"],"category_scores_codex":[0.0009670089,0.0003010217,0.0004059434,0.0007870994,0.001036227,0.00009290381,0.001125071,0.0003796624,0.001523964],"category_scores_gemma":[0.0005306138,0.0002656277,0.0001155093,0.001055343,0.0007622274,0.0006178776,0.0002262856,0.0007444248,0.001877425],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001685064,"about_ca_system_score_gemma":0.0005790833,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000334393,"about_ca_topic_score_gemma":0.00004019555,"domain_scores_codex":[0.9972612,0.000476314,0.0005439886,0.0008069489,0.00007934601,0.0008321679],"domain_scores_gemma":[0.9981906,0.0002393881,0.000231263,0.0009032821,0.0004007519,0.00003468306],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0007709383,0.0002264322,0.0005055182,0.000006307849,0.00004393668,0.000002785823,0.0002941149,0.000002710534,0.9840344,0.0009718434,0.004477072,0.008663987],"study_design_scores_gemma":[0.001006724,0.0006638321,0.009939907,0.00002814498,0.00002496448,0.0000380542,0.001328483,0.00001334994,0.8254356,0.0001160383,0.1611725,0.0002324171],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9478276,0.003628067,0.0001163735,0.0006309948,0.02251124,0.0002763698,0.000003280665,0.0002283106,0.02477772],"genre_scores_gemma":[0.9691804,0.0002988951,0.0000644254,0.001073556,0.00005095141,0.0000394121,0.00002956204,0.0000137595,0.02924901],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1585988,"threshold_uncertainty_score":0.9999796,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01034057392396839,"score_gpt":0.2768259724268634,"score_spread":0.266485398502895,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}