{"id":"W4411085959","doi":"10.1126/sciadv.ads6556","title":"CoREST in pieces: Dismantling the CoREST complex for cancer therapy and beyond","year":2025,"lang":"en","type":"review","venue":"Science Advances","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hôpital Maisonneuve-Rosemont; Université de Montréal; Institute for Research in Immunology and Cancer","funders":"Canadian Institutes of Health Research","keywords":"Corepressor; Transcription factor; Biology; Cell biology; Ubiquitin; Ubiquitin ligase; Cancer research; Repressor; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005065703,0.0007208789,0.0009532247,0.00143481,0.0002127617,0.000693316,0.000853455,0.001122631,0.003016445],"category_scores_gemma":[0.0004141983,0.0002340537,0.000386216,0.00101072,0.0005061696,0.001176265,0.0007178245,0.002066314,0.002122466],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006010535,"about_ca_system_score_gemma":0.0006008727,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005658134,"about_ca_topic_score_gemma":0.001343065,"domain_scores_codex":[0.999882,0.0000204616,0.00001465505,0.00002050152,0.0000462997,0.00001618281],"domain_scores_gemma":[0.9998478,0.00006397266,0.0000218885,0.000006431766,0.00003730717,0.00002260529],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001100812,0.00006151669,0.0001161045,0.00934841,0.00008477256,0.0002957857,0.0000517775,0.0004249131,0.00436438,0.006794326,0.04295294,0.9353949],"study_design_scores_gemma":[0.00001649184,0.00006766633,0.0002658426,0.0009301642,0.00004050955,0.001010583,0.00002289283,0.00008735988,0.0009297876,0.002014963,0.9946033,0.00001034697],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0001310402,0.997977,0.0002066026,0.0003737596,0.0003198677,0.000004121445,0.00001352378,0.00001052954,0.0009636353],"genre_scores_gemma":[0.0009365643,0.9969705,0.0002556831,0.0003472358,0.000219661,0.000007469922,0.00003624532,0.000003738976,0.001222817],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.003016445,"threshold_uncertainty_score":0.01009101,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06636976339017032,"score_gpt":0.4075914311164568,"score_spread":0.3412216677262865,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}