{"id":"W4411088246","doi":"10.7554/elife.105968.1","title":"The oneirogen hypothesis: modeling the hallucinatory effects of classical psychedelics in terms of replay-dependent plasticity mechanisms","year":2025,"lang":"en","type":"preprint","venue":"eLife","topic":"Psychedelics and Drug Studies","field":"Psychology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Université de Montréal; Mila - Quebec Artificial Intelligence Institute","funders":"","keywords":"Plasticity; Psychology; Cognitive psychology; Neuroscience; Computer science; Cognitive science; Physics; Thermodynamics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.001341286,0.0004530245,0.0008920287,0.0001761681,0.0001801855,0.00002826791,0.001233637,0.0005520936,0.00001183555],"category_scores_gemma":[0.0006812546,0.0002840005,0.0003761195,0.0001915726,0.0002254348,0.00001786948,0.001019712,0.001123042,0.00001274676],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00009469055,"about_ca_system_score_gemma":0.0001401692,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002844227,"about_ca_topic_score_gemma":0.0004165044,"domain_scores_codex":[0.9963598,0.000501985,0.001181531,0.0007699773,0.0006891005,0.0004976077],"domain_scores_gemma":[0.9955416,0.002248624,0.0005878693,0.001392897,0.0001591485,0.00006987021],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"theoretical_or_conceptual","study_design_gemma":"theoretical_or_conceptual","study_design_scores_codex":[0.003902989,0.006159987,0.006477885,0.005096067,0.009927081,0.0001583012,0.03519067,0.05134465,0.006545829,0.8072972,0.02104052,0.04685887],"study_design_scores_gemma":[0.01232761,0.001308637,0.04687437,0.008779987,0.002586631,0.00003666294,0.01103607,0.1560888,0.04738779,0.7051136,0.004380766,0.004079099],"study_design_candidate":"theoretical_or_conceptual","study_design_consensus":"theoretical_or_conceptual","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8562335,0.01467483,0.05279277,0.005231907,0.01250197,0.004290783,0.0003391958,0.000194956,0.05374005],"genre_scores_gemma":[0.9970877,0.0009208975,0.0004584087,0.0003456983,0.0001494272,0.0004265771,0.000003375271,0.00003849003,0.0005694744],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1408541,"threshold_uncertainty_score":0.9999612,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04377191004115193,"score_gpt":0.3220192880303427,"score_spread":0.2782473779891908,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}