{"id":"W4411088246","doi":"10.7554/elife.105968.1","title":"The oneirogen hypothesis: modeling the hallucinatory effects of classical psychedelics in terms of replay-dependent plasticity mechanisms","year":2025,"lang":"en","type":"preprint","venue":"eLife","topic":"Psychedelics and Drug Studies","field":"Psychology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Université de Montréal; Mila - Quebec Artificial Intelligence Institute","funders":"","keywords":"Plasticity; Psychology; Cognitive psychology; Neuroscience; Computer science; Cognitive science; Physics; Thermodynamics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002543644,0.0003483779,0.0002638175,0.0001935434,0.0001689185,0.0003442808,0.00079627,0.0006188172,0.001547236],"category_scores_gemma":[0.0007134685,0.0001774786,0.000550799,0.00007831203,0.0005724274,0.0005996705,0.000352088,0.0006129991,0.0001091138],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003271521,"about_ca_system_score_gemma":0.0003376784,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002361743,"about_ca_topic_score_gemma":0.002159507,"domain_scores_codex":[0.9999499,0.0000156659,0.000002846685,0.00001120825,0.000007740151,0.0000126352],"domain_scores_gemma":[0.99981,0.00009107575,0.00004343148,0.00001971226,0.00001773297,0.00001806161],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"simulation_or_modeling","study_design_gemma":"simulation_or_modeling","study_design_scores_codex":[0.00005722793,0.00005777812,0.001246583,0.0000353623,0.0000260456,0.00008771941,0.00002901454,0.9841627,0.00643841,0.005472726,0.0001410035,0.002245447],"study_design_scores_gemma":[0.000004846962,0.00001969914,0.0001932933,0.00000139098,0.000003015779,0.000006766762,0.000003128398,0.9980091,0.0003847695,0.001335768,0.00003623543,0.000001938532],"study_design_candidate":"simulation_or_modeling","study_design_consensus":"simulation_or_modeling","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.7881452,0.0002050893,0.204717,0.0005606338,0.00005181624,0.00006263836,0.0001475327,0.0002594867,0.00585051],"genre_scores_gemma":[0.9915742,0.0000592909,0.007413067,0.00003919267,0.000005432768,0.00004020575,0.00002628778,0.00001219242,0.0008301425],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002361743,"threshold_uncertainty_score":0.005176067,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04377191004115193,"score_gpt":0.3220192880303427,"score_spread":0.2782473779891908,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}