{"id":"W4411088616","doi":"10.1021/ehp.6c00142","title":"Prenatal Smoking Exposures and Epigenome-Wide Methylation in Newborn Blood","year":2025,"lang":"en","type":"article","venue":"Environmental Health Perspectives","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"NHLBI Division of Intramural Research; Eunice Kennedy Shriver National Institute of Child Health and Human Development; National Institute of Child Health and Human Development; National Institute of Environmental Health Sciences; Norwegian Institute of Public Health; Agencia Estatal de Investigación; Agència de Gestió d'Ajuts Universitaris i de Recerca; Medical Research Council; Anschutz Medical Campus, University of Colorado; University of North Carolina at Chapel Hill; Universiteit Hasselt; Université de Montpellier; University of Cape Town; Universitat de Barcelona; Directorate for Biological Sciences; National Institutes of Health; Rijksuniversiteit Groningen; Generalitat de Catalunya; Sorbonne Université; NYU Grossman School of Medicine; Institut National de la Santé et de la Recherche Médicale; Universitair Medisch Centrum Groningen; Helmholtz-Zentrum für Umweltforschung; National Cancer Institute; University of Bristol; Universität Heidelberg; South African Medical Research Council; Universitat Pompeu Fabra; York University; Horizon 2020; University of Exeter; Texas Children's Hospital; Universitetet i Bergen; North Carolina State University; Emory University; University of Southern California","keywords":"Epigenome; DNA methylation; Prenatal exposure; Medicine; Environmental health; Pregnancy; Methylation; Biology; Physiology; Bioinformatics; Genetics; Offspring; DNA; Gene","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001597573,0.000397109,0.0006814532,0.0009256882,0.000241124,0.0006892374,0.0004917866,0.000415553,0.001262369],"category_scores_gemma":[0.003644653,0.0002868259,0.002240673,0.0016481,0.0002262162,0.0002804817,0.0004953563,0.0004353778,0.0001110338],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004283395,"about_ca_system_score_gemma":0.0004463149,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.005528153,"about_ca_topic_score_gemma":0.006752357,"domain_scores_codex":[0.9987752,0.0003749683,0.00010142,0.000469656,0.0001945495,0.0000841808],"domain_scores_gemma":[0.9982199,0.0009169439,0.000433979,0.0002256725,0.0001248054,0.00007864627],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001102487,0.00002526345,0.9372533,0.0009918213,0.02217443,0.0002309779,0.0001449357,0.001098306,0.008214074,0.0002622787,0.0009442231,0.02755793],"study_design_scores_gemma":[0.0000570186,0.000166478,0.9797738,0.0001753082,0.01200977,0.0004976935,0.00007055343,0.001106296,0.00276645,0.0005835882,0.002777279,0.0000157319],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9086309,0.07373986,0.007708398,0.0006288598,0.000141278,0.00003589592,0.007023652,0.0001577233,0.001933456],"genre_scores_gemma":[0.9909869,0.00534518,0.001671341,0.0001905808,0.00003215285,0.00003830883,0.001378112,0.00002283257,0.0003346841],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005528153,"threshold_uncertainty_score":0.01099193,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006418033084365191,"score_gpt":0.2671691159819715,"score_spread":0.2607510828976063,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}