{"id":"W4411090422","doi":"10.1093/molbev/msaf115","title":"Tripartite Loops Reverse Antibiotic Resistance","year":2025,"lang":"en","type":"article","venue":"Molecular Biology and Evolution","topic":"Evolution and Genetic Dynamics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"Concordia University","funders":"Fonds de Recherche du Québec - Santé; Uniwersytet Łódzki","keywords":"Biology; Antibiotics; Antibiotic resistance; Drug resistance; Resistance (ecology); Genetics; Computational biology; Ecology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000245963,0.0003018156,0.0002563239,0.0002270356,0.0002004837,0.0004470356,0.0004278893,0.0004366208,0.001749166],"category_scores_gemma":[0.0007718528,0.00016491,0.0002714135,0.0001236377,0.0004156471,0.0003970887,0.0005971714,0.0008312968,0.0003029705],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003420922,"about_ca_system_score_gemma":0.0002688632,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002097507,"about_ca_topic_score_gemma":0.0004278447,"domain_scores_codex":[0.9997241,0.0000710673,0.00001850362,0.00006044187,0.00007519616,0.00005065832],"domain_scores_gemma":[0.9995199,0.0001338895,0.0001489539,0.00008766062,0.00004437631,0.00006528894],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009208409,0.00006605293,0.0004932083,0.00005483464,0.00001526434,0.00004358739,0.00002918106,0.001186803,0.9839683,0.001392945,0.0001018107,0.01255607],"study_design_scores_gemma":[0.00004297008,0.002058332,0.003898653,0.000022932,0.0000552952,0.0007728476,0.00006021742,0.01390377,0.9669027,0.001952423,0.01029486,0.00003491737],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9759376,0.0009534484,0.01975675,0.0002235373,0.0000600073,0.0000610216,0.00007561935,0.0002710622,0.002660953],"genre_scores_gemma":[0.987572,0.0003289568,0.01042364,0.0001511934,0.00001099723,0.00004191551,0.00007353246,0.00004489671,0.001352906],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001749166,"threshold_uncertainty_score":0.005851507,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00280991436465121,"score_gpt":0.2569461657008971,"score_spread":0.2541362513362459,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}