{"id":"W4411091678","doi":"10.59368/agingbio.20250040","title":"Genetic Dissection Reveals New Components of the NHR-49 Multi-Stress Resistance and Longevity Pathway","year":2025,"lang":"en","type":"article","venue":"","topic":"Genetics, Aging, and Longevity in Model Organisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"AbCellera (Canada); Toronto General Hospital; University of Toronto; BC Children's Hospital; Kwantlen Polytechnic University; University of British Columbia","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; National Institutes of Health; Universities Space Research Association; BC Children's Hospital","keywords":"Longevity; Resistance (ecology); Biology; Genetics; Evolutionary biology; Ecology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008437898,0.0005693818,0.0002020784,0.0003394011,0.0001519052,0.0002348766,0.0003223686,0.0002979264,0.001692113],"category_scores_gemma":[0.00007511787,0.0001846078,0.0003534556,0.0001146472,0.0002143966,0.0001614134,0.0002819311,0.0004061944,0.0007636444],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003655425,"about_ca_system_score_gemma":0.0002317584,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007137501,"about_ca_topic_score_gemma":0.0009809732,"domain_scores_codex":[0.9999113,0.000007928568,0.0000101007,0.00002624979,0.00002191613,0.00002245154],"domain_scores_gemma":[0.9998732,0.00001878743,0.00005257757,0.00001446662,0.00000791568,0.0000331265],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004688305,0.00001277852,0.0001586276,0.000008922554,0.000003038353,0.0001034925,0.000003059848,0.00006143221,0.9989536,0.0001197119,0.00001845888,0.000509832],"study_design_scores_gemma":[0.00004027275,0.000161549,0.01881378,0.00001308929,0.00004436336,0.0009778652,0.00004080059,0.004265319,0.9701149,0.00022446,0.005287144,0.00001646406],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9884006,0.0005697221,0.006936458,0.0001423584,0.00003251339,0.00004968198,0.001027648,0.0002196338,0.002621434],"genre_scores_gemma":[0.989261,0.0004746582,0.004271023,0.00009150179,0.00001127857,0.00004806082,0.001859989,0.00005916483,0.003923315],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001692113,"threshold_uncertainty_score":0.005660713,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01187526887089887,"score_gpt":0.2355978692250152,"score_spread":0.2237226003541163,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}