{"id":"W4411099129","doi":"10.1515/jnhpr-2021-030101","title":"An In Vitro Evaluation of the Inhibition of Recombinant Human Carboxylesterase-1 by Herbal Extracts","year":2021,"lang":"en","type":"article","venue":"Journal of Natural Health Product Research","topic":"Cholinesterase and Neurodegenerative Diseases","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Children's Hospital of Eastern Ontario; University of Ottawa","funders":"University of Ottawa","keywords":"Carboxylesterase; In vitro; Recombinant DNA; Pharmacology; Chemistry; Traditional medicine; Biology; Enzyme; Medicine; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.005323495,0.00008624013,0.0003577049,0.0002392775,0.00009368382,0.00001146842,0.00009910779,0.00002868783,0.00001707929],"category_scores_gemma":[0.001233038,0.00005583779,0.00009621194,0.0006872039,0.00008887606,0.000197113,0.00003367346,0.0008654135,2.535132e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003024068,"about_ca_system_score_gemma":0.002197695,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001358173,"about_ca_topic_score_gemma":0.0001080562,"domain_scores_codex":[0.9948452,0.002261129,0.0008019514,0.0001973452,0.0016456,0.0002488433],"domain_scores_gemma":[0.9955795,0.0001104013,0.0004209944,0.0003107272,0.003432659,0.0001457072],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006268221,0.001077737,0.005006172,0.000369134,0.00001289399,0.00002836865,0.0004385478,0.00001134323,0.9823641,0.000007676888,0.001722959,0.008334248],"study_design_scores_gemma":[0.002051409,0.0004766828,0.1417871,0.0007198359,0.00002355873,0.0001259895,0.0002407675,0.00008606046,0.8542622,0.0001049743,0.00007941362,0.00004206126],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9816597,0.009672642,2.800197e-7,0.007836647,0.0002883297,0.0005188159,0.000008775221,0.000001481281,0.00001333101],"genre_scores_gemma":[0.9990846,0.0002737468,0.00005583099,0.0001983344,0.0002617868,0.000004834395,0.00003628196,0.00001052988,0.00007404014],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1367809,"threshold_uncertainty_score":0.3898617,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1634189347684553,"score_gpt":0.5071262790092661,"score_spread":0.3437073442408108,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}