{"id":"W4411100032","doi":"10.1186/s12933-025-02781-x","title":"Treatment with orforglipron, an oral glucagon like peptide-1 receptor agonist, is associated with improvements of CV risk biomarkers in participants with type 2 diabetes or obesity without diabetes","year":2025,"lang":"en","type":"article","venue":"Cardiovascular Diabetology","topic":"Diabetes Treatment and Management","field":"Medicine","cited_by":18,"is_retracted":false,"has_abstract":true,"ca_institutions":"York University","funders":"Eli Lilly and Company","keywords":"Medicine; Internal medicine; Dulaglutide; Endocrinology; Diabetes mellitus; Type 2 diabetes; Glycemic; Overweight; Lipid profile; Placebo; Obesity; Glucagon-like peptide 1 receptor; Exenatide; Agonist; Receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001381625,0.0003937841,0.001097345,0.000266308,0.0001722242,0.0004557614,0.0002139453,0.0005502664,0.002318667],"category_scores_gemma":[0.00140379,0.0001878743,0.001125088,0.0003028729,0.0002615282,0.000312945,0.000287538,0.0006453705,0.0001373994],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001235497,"about_ca_system_score_gemma":0.0002572597,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003468815,"about_ca_topic_score_gemma":0.0008338896,"domain_scores_codex":[0.9994352,0.0002715883,0.00004557308,0.0001030952,0.00007730514,0.00006711329],"domain_scores_gemma":[0.9990078,0.0003325211,0.0003642829,0.00005135589,0.00004692383,0.0001971846],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"observational","study_design_scores_codex":[0.5475951,0.009096436,0.2592704,0.001649245,0.007521698,0.0004117339,0.0003506945,0.0007706785,0.08611549,0.00009802676,0.001210328,0.0859102],"study_design_scores_gemma":[0.01795036,0.08557602,0.8827729,0.0001285653,0.003611568,0.000388425,0.000262166,0.0009790455,0.006736266,0.0001653591,0.001381141,0.0000482321],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.996885,0.002128034,0.0001967052,0.00006127705,0.00002242288,0.00005628463,0.0002858222,0.00001158837,0.0003528602],"genre_scores_gemma":[0.9980288,0.0006598661,0.0004150321,0.0001097784,0.00003322433,0.00009296184,0.0003488647,0.000003570453,0.0003078657],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002318667,"threshold_uncertainty_score":0.00775677,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01573269884666853,"score_gpt":0.2545787569961747,"score_spread":0.2388460581495061,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}